Importance The antiepileptic drug phenytoin can cause cutaneous adverse reactions,
ranging from maculopapular exanthema to severe cutaneous adverse reactions, which …

Introduction: Phenytoin, a widely prescribed old-generation antiepileptic drug, requires
careful individualization of dosage to compensate for its prominent pharmacokinetic …

To develop a pre‐emptive genetic test that comprises multiple predisposing alleles for the
prevention of phenytoin‐related severe cutaneous adverse reactions (SCARs), three sets of …

Background Phenytoin is one of the most common causative drugs of several types of
severe cutaneous adverse reactions (SCAR) such as Stevens–Johnson syndrome (SJS) …

Purpose The purpose of this study was to investigate the association of genetic factors
including variants in HLA-B and CYP2C genes and non-genetic factors with phenotype …

Importance of the field: Recent advances in pharmacogenetic studies have uncovered
increasingly more genes that predispose individuals to adverse drug reactions. Aromatic …

Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe,
cutaneous adverse drug reactions that are rare but life threatening. Genetic biomarkers for …

Abstract Cytochrome P450 (CYP) 2C9 is the principal enzyme responsible for the
metabolism of numerous clinically important drugs. Two polymorphic alleles CYP2C9* 2 and …

Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large
interpatient variability, partly due to genetic variations in the gene encoding cytochrome …

Background Apart from allergic mechanisms, a lack or mutation of metabolic enzymes may
cause adverse drug reactions. Patch testing has rarely been useful in cutaneous adverse …