Although tianeptine, an atypical antidepressant has been reported to have antinociceptive
effects, the mode of action is different from that of tricyclic antidepressants despite structural …

The purpose of this study was to validate the effects of tianeptine on serotonergic and
noradrenergic neurotransmission in a rat model of neuropathic pain. Neuropathic pain was …

BACKGROUND: Tianeptine is an atypical antidepressant that exhibits structural similarities
to the tricyclic antidepressants but has distinct neurochemical properties. We evaluated the …

Background: Spinal nerve-ligated neuropathy and chemotherapy-induced neuropathy
produce a persistent tactile allodynia in mice. Tianeptine is an antidepressant that exhibits …

Triptolide (T10), an active component of Tripterygium wilfordii Hook F, is reported to have
potent anti-inflammatory and analgesic effects. Additionally, MK-801, a noncompetitive N …

There is an association between depression and chronic pain, and some antidepressants
exert antinociceptive effects in humans and laboratory animals. We examined the effects of …

Nefopam is a non-opioid analgesic drug, used widely in European countries to control
postoperative pain. However, its mechanism of action remains unclear. In this study, the …

Antidepressants, especially tricyclic antidepressants (TCAs) are widely used for the
treatment of various types of chronic and neuropathic pain. The antinociceptive effects of …

Antidepressants are one of the first line treatments for neuropathic pain but their use is
limited by the incidence and severity of side effects of tricyclics and the weak effectiveness of …

Tianeptine is an unusual tricyclic antidepressant drug. In this study, we aimed to investigate
the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether …