Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression

MLS Lindegaard, P Damm, ER Mathiesen… - Journal of lipid …, 2006 - ASBMB
Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …

The effect of high glucose on lipid metabolism in the human placenta

CH Hulme, A Nicolaou, SA Murphy, AEP Heazell… - Scientific reports, 2019 - nature.com
Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to
placental dysfunction, which has health consequences for the infant. Here we test our …

Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM)

HL Barrett, MH Kubala, K Scholz Romero, KJ Denny… - PLoS …, 2014 - journals.plos.org
Infants of women with gestational diabetes mellitus (GDM) are more likely to be born large
for gestational age with a higher percentage body fat. Elevated maternal lipids may …

Placental lipoprotein lipase activity is positively associated with newborn adiposity

MJR Heerwagen, DL Gumina, TL Hernandez… - Placenta, 2018 - Elsevier
Introduction Recent data suggest that in addition to glucose, fetal growth is related to
maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids …

Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice

L Qiao, Z Guo, C Bosco, S Guidotti, Y Wang… - Diabetes, 2015 - Am Diabetes Assoc
This study investigated how maternal overnutrition and obesity regulate expression and
activation of proteins that facilitate lipid transport in the placenta. To create a maternal …

Insulin treatment may alter fatty acid carriers in placentas from gestational diabetes subjects

M Ruiz-Palacios, MT Prieto-Sánchez… - International Journal of …, 2017 - mdpi.com
There is little information available on the effect of Gestational diabetes mellitus (GDM)
treatment (diet or insulin) on placental lipid carriers, which may influence fetal fat accretion …

Modulation of cholesterol transport by insulin-treated gestational diabetes mellitus in human full-term placenta

E Dubé, M Ethier-Chiasson, J Lafond - Biology of reproduction, 2013 - academic.oup.com
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that is
characterized by glucose intolerance, leads to dyslipidemia, and is aggravated by obesity …

Placental accumulation of triacylglycerols in gestational diabetes mellitus and its association with altered fetal growth are related to the differential expressions of …

M Balachandiran, Z Bobby, G Dorairajan… - Experimental and …, 2021 - thieme-connect.com
Introduction Gestational diabetes mellitus (GDM) exhibit altered placental lipid metabolism.
The molecular basis of this altered metabolism is not clear. Altered placental expression of …

Placental lipoprotein lipase DNA methylation levels are associated with gestational diabetes mellitus and maternal and cord blood lipid profiles

AA Houde, J St-Pierre, MF Hivert… - … origins of health and …, 2014 - cambridge.org
Placental lipoprotein lipase (LPL) is crucial for placental lipid transfer. Impaired LPL gene
expression and activity were reported in pregnancies complicated by gestational diabetes …

BMI-independent effects of gestational diabetes on human placenta

L Stirm, M Kovářová, S Perschbacher… - The Journal of …, 2018 - academic.oup.com
Purpose Recently, alterations in maternal lipid metabolism were associated with gestational
diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for …