Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression
MLS Lindegaard, P Damm, ER Mathiesen… - Journal of lipid …, 2006 - ASBMB
Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …
The effect of high glucose on lipid metabolism in the human placenta
Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to
placental dysfunction, which has health consequences for the infant. Here we test our …
placental dysfunction, which has health consequences for the infant. Here we test our …
Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM)
Infants of women with gestational diabetes mellitus (GDM) are more likely to be born large
for gestational age with a higher percentage body fat. Elevated maternal lipids may …
for gestational age with a higher percentage body fat. Elevated maternal lipids may …
Placental lipoprotein lipase activity is positively associated with newborn adiposity
MJR Heerwagen, DL Gumina, TL Hernandez… - Placenta, 2018 - Elsevier
Introduction Recent data suggest that in addition to glucose, fetal growth is related to
maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids …
maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids …
Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice
L Qiao, Z Guo, C Bosco, S Guidotti, Y Wang… - Diabetes, 2015 - Am Diabetes Assoc
This study investigated how maternal overnutrition and obesity regulate expression and
activation of proteins that facilitate lipid transport in the placenta. To create a maternal …
activation of proteins that facilitate lipid transport in the placenta. To create a maternal …
Insulin treatment may alter fatty acid carriers in placentas from gestational diabetes subjects
M Ruiz-Palacios, MT Prieto-Sánchez… - International Journal of …, 2017 - mdpi.com
There is little information available on the effect of Gestational diabetes mellitus (GDM)
treatment (diet or insulin) on placental lipid carriers, which may influence fetal fat accretion …
treatment (diet or insulin) on placental lipid carriers, which may influence fetal fat accretion …
Modulation of cholesterol transport by insulin-treated gestational diabetes mellitus in human full-term placenta
E Dubé, M Ethier-Chiasson, J Lafond - Biology of reproduction, 2013 - academic.oup.com
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that is
characterized by glucose intolerance, leads to dyslipidemia, and is aggravated by obesity …
characterized by glucose intolerance, leads to dyslipidemia, and is aggravated by obesity …
Placental accumulation of triacylglycerols in gestational diabetes mellitus and its association with altered fetal growth are related to the differential expressions of …
M Balachandiran, Z Bobby, G Dorairajan… - Experimental and …, 2021 - thieme-connect.com
Introduction Gestational diabetes mellitus (GDM) exhibit altered placental lipid metabolism.
The molecular basis of this altered metabolism is not clear. Altered placental expression of …
The molecular basis of this altered metabolism is not clear. Altered placental expression of …
Placental lipoprotein lipase DNA methylation levels are associated with gestational diabetes mellitus and maternal and cord blood lipid profiles
AA Houde, J St-Pierre, MF Hivert… - … origins of health and …, 2014 - cambridge.org
Placental lipoprotein lipase (LPL) is crucial for placental lipid transfer. Impaired LPL gene
expression and activity were reported in pregnancies complicated by gestational diabetes …
expression and activity were reported in pregnancies complicated by gestational diabetes …
BMI-independent effects of gestational diabetes on human placenta
L Stirm, M Kovářová, S Perschbacher… - The Journal of …, 2018 - academic.oup.com
Purpose Recently, alterations in maternal lipid metabolism were associated with gestational
diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for …
diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for …