Introduction: In the parathyroid gland, the calcium sensing receptor responds to small
changes in circulating levels of Ca2+, and consequently stimulates or inhibits the secretion …

The only bone anabolic agents currently available on the market are based on the
parathyroid hormone (PTH). Secretion of endogenous PTH is controlled by a calcium …

The cell surface calcium receptor (Ca2+ receptor) is a particularly difficult receptor to study
because its primary physiological ligand, Ca2+, affects numerous biological processes both …

Calcimimetic agents are small organic molecules that act as allosteric activators of the
calcium sensing receptor. They lower the threshold for receptor activation by extracellular …

Publisher Summary This chapter reviews the progress made in the discovery and
development of small molecules that activate or inhibit the parathyroid Ca 2+ receptor and …

The calcium sensing receptor (CaR) is a G protein-coupled receptor (GPCR) that plays a
fundamental role in serum calcium homeostasis. The CaR is expressed on the chief cells of …

Parathyroid cells can sense small changes in plasma Ca 2+ levels by virtue of a cell surface
Ca 2+ receptor. Calcimimetics are newly synthesized compounds that act as agonists or …

Circulating levels of calcium ion (Ca2+) are maintained within a narrow physiological range
mainly by the action of parathyroid hormone (PTH) secreted from parathyroid gland (PTG) …

Calcimimetics are new drugs whose name reflects their major action: to mimic the effect of
calcium on calcium receptors. The research that has led to the design of these drugs has …

The actions of extracellular Ca 2+ in regulating parathyroid gland and kidney functions are
mediated by the extracellular calcium receptor (CaR), a G protein-coupled receptor. The …