Lung transplantation remains the only effective therapy for patients with end-stage lung
disease, but survival is limited by the development of obliterative bronchiolitis (OB). The …

Acute allograft rejection is a major complication postlung transplantation and is the main risk
factor for the development of bronchiolitis obliterans syndrome. Acute rejection is …

BACKGROUND: Long-term success in lung transplantation is limited by obliterative
bronchiolitis (OB), yet the mechanism for this disease is not well understood. Chemokine …

Chemokines and chemokine receptors have been implicated in the pathogenesis of
bronchiolitis. CXCR3 ligands (CXCL10, CXCL9, and CXCL11) were elevated in patients …

Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival post-lung
transplantation and is characterized by a persistent peribronchiolar inflammation that …

Lung transplantation is a therapeutic option for a number of end-stage pulmonary disorders.
Early lung allograft dysfunction (ischemia-reperfusion injury) continues to be the most …

Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival after lung
transplantation. Acute rejection, its main risk factor, is characterized by perivascular …

Angiogenesis and vascular remodeling support fibroproliferative processes; however, no
study has addressed the importance of angiogenesis during fibro-obliteration of the allograft …

CXCR3 is a chemokine receptor preferentially expressed on lymphocytes, particularly on
type-1 T-lymphocytes. Smokers who develop chronic obstructive pulmonary disease …

The attraction of T lymphocytes into the pulmonary parenchyma represents an essential step
in mechanisms ultimately leading to lung allograft rejection. In this study we evaluated …