Pain is a symptom of ninety percent of human diseases, and pain management is a very
important medicinal problem. Various modulators of the pain response have been detected …

Existing analgesic drugs are small in number, limited in efficacy and associated with
significant side-effects. There is, therefore, a need for new pain medications. In the last …

Opioids are a largely efficient medica-tion for relieving severe pain and are prescribed for a
wide variety of indications including metastatic cancer, arthritis, neuropathy or post-surgical …

Despite intensive research into pain mechanisms and significant investment in research and
development, the majority of analgesics available to prescribers and patients are based on …

Introduction Neuropathic pain is characterized by abnormal pain sensations, including
spontaneous pain, hyperalgesia (ie, increased sensitivity to a noxious stimulus) and …

Publisher Summary This chapter focuses on recent advances toward pain therapeutics. Two
of the most promising novel targets actively pursued for chronic pain are the voltage-gated …

Management of pain is a fundamental imperative in medicine. Current analgesics suffer from
limitations related to efficacy and adverse events of which abuse potential has assumed an …

Pain is the most common reason for patients seeking medical care resulting in an estimated
world market for analgesics of more than USD 50 billion. Pain is a highly complex …

The pharmacotherapy for pain is dominated by conventional analgesics such as the opioids
and the non-steroidal anti-inflammatory drugs. Recent advances in the understanding of the …

There is a considerable need for novel analgesics that are more effective or safer than
existing drugs. Richard Silverman highlights some of the research that led to the discovery of …