Abstract Oligonucleotides containing 2′-O, 4′-C-ethylene nucleic acids (ENA) have been
proven highly effective for antisense therapeutics. 2′-O, 4′-C-Ethyleneguanosine and its …

Novel bicyclo nucleosides, 2′-O, 4′-C-ethylene nucleosides and 2′-O, 4′-C-propylene
nucleosides, were synthesized as building blocks for antisense oligonucleotides to further …

O, 4′‐C‐Ethylene‐bridged nucleic acid (ENA) is a sugar‐modified oligonucleotide with an
ethylene bridge between the 2′‐oxygen and 4′‐carbon of ribose. ENA not only has as …

Novel 2-O, 4-C-ethylene nucleosides have been synthesized as building blocks for
antisense and antigene oligonucleotides. 2-O, 4-C-Ethylene-bridged nucleic acids (ENATM) …

A phosphoramidite of 3ʹ-O, 4ʹ-C-ethyleneoxy-bridged 5-methyluridine (3ʹ, 4ʹ-EoNA-T)
was successfully incorporated into oligonucleotides, and their abilities to form duplexes with …

2′-O, 4′-C-methylene-linked ribonucleotide derivatives, named LNA (locked nucleic acid)
and BNA (bridged nucleic acid) are nucleic acid analogoues that have shown high-affinity …

Abstract Novel 2′‐O, 4′‐C‐ethylene‐bridged nucleic acid (ENA) analogs with exocyclic
methylene and (R)‐methyl groups at the 6′‐position were synthesized. The obtained 6 …

Antigenes, which are substances that inhibit gene expression by binding to double‐stranded
DNA (dsDNA) in a sequence‐specific manner, are currently sought for the treatment of …

Abstract Derivatives of 2'‐O‐4'‐C‐Ethylene‐bridged Nucleic Acid (ENA) monomer, a
nucleoside used in the preparation of antisense modified oligonucleotides and featuring an …

2′-O, 4′-C-Ethyleneoxy bridged 5-methyluridine (EoNA-T), possessing a seven-
membered linkage and an anomeric 4′-carbon, was synthesized and introduced into …