The aim of this study was to determine the brain structures as well as the plasticity events
associated with the behavioral effects of cholinergic damage. Rats were submitted to …

To study the effect of reduced cortical cholinergic activity on GABAergic and glutamatergic
mechanisms in cholinoceptive cortical target regions a novel cholinergic immunotoxin …

Use of the selective immunotoxin; 192 IgG-saporin, is helping to elucidate the role of the
cholinergic system in cognition by overcoming the problems of interpretation associated with …

The degree of lesion produced by 192 IgG-saporin relative to controls was compared using
three independent methods. Microdialyzed acetylcholine (ACh), choline acetyltransferase …

Immunolesions of the cholinergic basal forebrain were produced in rats using various
intraventricular doses of the immunotoxin 192 immunoglobulin G-saporin: 0.34, 1.34, 2.0 …

The present experiment was designed to study changes in behavior following
immunolesioning of the basal forebrain cholinergic system. Rats were lesioned at 3 months …

The elucidation of the functional role of the basal forebrain cholinergic system will require
access to a highly specific and efficient cholinergic neurotoxin. Recently, selective depletion …

Increasing numbers of reports have substantiated to date, a beneficial influence of cytokine
treatment on neurogenesis processes in damaged rodent brains. Most of these …

Selective removal of the basal forebrain cholinergic neurons by the immunotoxin 192
immunoglobulin G-saporin has offered a new powerful tool for the study of the relationships …

Selective depletion of nerve growth factor receptor‐bearing neurons in the basal forebrain
cholinergic nuclei by the immunotoxin 192 IgG‐saporin offers a new and highly useful tool …