An Antivirulence approach for preventing Cryptococcus neoformans from crossing the blood-brain barrier via novel natural product inhibitors of a fungal …

PA Aaron, K Vu, A Gelli - MBio, 2020 - Am Soc Microbiol
Cryptococcus neoformans (Cn) is the leading cause of fungal meningitis, a deadly disease
with limited therapeutic options. Dissemination to the central nervous system hinges on the …

Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease

K Vu, R Tham, JP Uhrig, GR Thompson III… - MBio, 2014 - Am Soc Microbiol
Cryptococcus spp. cause life-threatening fungal infection of the central nervous system
(CNS), predominantly in patients with a compromised immune system. Why Cryptococcus …

[HTML][HTML] The structure-function analysis of the Mpr1 metalloprotease determinants of activity during migration of fungal cells across the blood-brain barrier

S Na Pombejra, M Jamklang, JP Uhrig, K Vu, A Gelli - PLoS One, 2018 - journals.plos.org
Cryptococcal meningoencephalitis, the most common form of cryptococcosis, is caused by
the opportunistic fungal pathogen, Cryptococcus neoformans. Molecular strategies used by …

Harnessing the Activity of the Fungal Metalloprotease, Mpr1, To Promote Crossing of Nanocarriers through the Blood–Brain Barrier

PA Aaron, A Gelli - ACS Infectious Diseases, 2019 - ACS Publications
Cryptococcus neoformans (Cn) is the leading cause of fungal meningitis primarily in
immunosuppressed patients. Cn invades the central nervous system by overcoming the …

[HTML][HTML] Cryptococcal meningitis and anti-virulence therapeutic strategies

K Vu, JA Garcia, A Gelli - Frontiers in microbiology, 2019 - frontiersin.org
Fungal infections of the central nervous system are responsible for significant morbidity and
mortality. Cryptococcus neoformans (Cn) is the primary cause of fungal meningitis. Infection …

[HTML][HTML] The anti-helminthic compound mebendazole has multiple antifungal effects against Cryptococcus neoformans

LS Joffe, R Schneider, W Lopes, R Azevedo… - Frontiers in …, 2017 - frontiersin.org
Cryptococcus neoformans is the most lethal pathogen of the central nervous system. The
gold standard treatment of cryptococcosis, a combination of amphotericin B with 5 …

[HTML][HTML] Novel cell-based in vitro screen to identify small-molecule inhibitors against intracellular replication of Cryptococcus neoformans in macrophages

S Samantaray, JN Correia, M Garelnabi, K Voelz… - International Journal of …, 2016 - Elsevier
The fungal pathogen Cryptococcus neoformans poses a major threat to
immunocompromised patients and is a leading killer of human immunodeficiency virus (HIV) …

In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus

KJ Shaw, WA Schell, J Covel, G Duboc… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans, is uniformly
fatal if not treated. Treatment options are limited, especially in resource-poor geographical …

A High-Throughput Screening Assay for Fungicidal Compounds against Cryptococcus neoformans

JLA Rabjohns, YD Park, J Dehdashti… - Journal of …, 2014 - journals.sagepub.com
Cryptococcus neoformans is a pathogenic fungus that causes meningitis worldwide,
particularly in human immunodeficiency virus (HIV)–infected individuals. Although …

[HTML][HTML] De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

CA Morrow, E Valkov, A Stamp, EWL Chow, IR Lee… - 2012 - journals.plos.org
We have investigated the potential of the GTP synthesis pathways as chemotherapeutic
targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal …