An Antivirulence approach for preventing Cryptococcus neoformans from crossing the blood-brain barrier via novel natural product inhibitors of a fungal …
PA Aaron, K Vu, A Gelli - MBio, 2020 - Am Soc Microbiol
Cryptococcus neoformans (Cn) is the leading cause of fungal meningitis, a deadly disease
with limited therapeutic options. Dissemination to the central nervous system hinges on the …
with limited therapeutic options. Dissemination to the central nervous system hinges on the …
Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease
K Vu, R Tham, JP Uhrig, GR Thompson III… - MBio, 2014 - Am Soc Microbiol
Cryptococcus spp. cause life-threatening fungal infection of the central nervous system
(CNS), predominantly in patients with a compromised immune system. Why Cryptococcus …
(CNS), predominantly in patients with a compromised immune system. Why Cryptococcus …
[HTML][HTML] The structure-function analysis of the Mpr1 metalloprotease determinants of activity during migration of fungal cells across the blood-brain barrier
Cryptococcal meningoencephalitis, the most common form of cryptococcosis, is caused by
the opportunistic fungal pathogen, Cryptococcus neoformans. Molecular strategies used by …
the opportunistic fungal pathogen, Cryptococcus neoformans. Molecular strategies used by …
Harnessing the Activity of the Fungal Metalloprotease, Mpr1, To Promote Crossing of Nanocarriers through the Blood–Brain Barrier
PA Aaron, A Gelli - ACS Infectious Diseases, 2019 - ACS Publications
Cryptococcus neoformans (Cn) is the leading cause of fungal meningitis primarily in
immunosuppressed patients. Cn invades the central nervous system by overcoming the …
immunosuppressed patients. Cn invades the central nervous system by overcoming the …
[HTML][HTML] Cryptococcal meningitis and anti-virulence therapeutic strategies
K Vu, JA Garcia, A Gelli - Frontiers in microbiology, 2019 - frontiersin.org
Fungal infections of the central nervous system are responsible for significant morbidity and
mortality. Cryptococcus neoformans (Cn) is the primary cause of fungal meningitis. Infection …
mortality. Cryptococcus neoformans (Cn) is the primary cause of fungal meningitis. Infection …
[HTML][HTML] The anti-helminthic compound mebendazole has multiple antifungal effects against Cryptococcus neoformans
Cryptococcus neoformans is the most lethal pathogen of the central nervous system. The
gold standard treatment of cryptococcosis, a combination of amphotericin B with 5 …
gold standard treatment of cryptococcosis, a combination of amphotericin B with 5 …
[HTML][HTML] Novel cell-based in vitro screen to identify small-molecule inhibitors against intracellular replication of Cryptococcus neoformans in macrophages
S Samantaray, JN Correia, M Garelnabi, K Voelz… - International Journal of …, 2016 - Elsevier
The fungal pathogen Cryptococcus neoformans poses a major threat to
immunocompromised patients and is a leading killer of human immunodeficiency virus (HIV) …
immunocompromised patients and is a leading killer of human immunodeficiency virus (HIV) …
In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus
KJ Shaw, WA Schell, J Covel, G Duboc… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans, is uniformly
fatal if not treated. Treatment options are limited, especially in resource-poor geographical …
fatal if not treated. Treatment options are limited, especially in resource-poor geographical …
A High-Throughput Screening Assay for Fungicidal Compounds against Cryptococcus neoformans
JLA Rabjohns, YD Park, J Dehdashti… - Journal of …, 2014 - journals.sagepub.com
Cryptococcus neoformans is a pathogenic fungus that causes meningitis worldwide,
particularly in human immunodeficiency virus (HIV)–infected individuals. Although …
particularly in human immunodeficiency virus (HIV)–infected individuals. Although …
[HTML][HTML] De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans
We have investigated the potential of the GTP synthesis pathways as chemotherapeutic
targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal …
targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal …