[目的] 腫瘍浸潤間質細胞 (Tumor-In 丘 litrating StromaCells, TISC) は, 腫瘍と同様に腫瘍環境下
での免疫抑制の一因を担っていると考えられてきた. しかし, uSC は腫瘍内に含有される割合が …

Tumor‐infiltrating stroma cells (TISC) as well as tumors themselves are thought to be
involved in tumor‐related immunosuppression, which is one of the critical mechanisms of …

Cancer stem cells are a distinct cellular population that is believed to be responsible for
tumor initiation and maintenance. Recent data suggest that solid tumors also contain …

MATERIALS AND METHODS Cancer cell lines and culture conditions. The human lung
cancer cell lines A549, NCI-H1299, and NCI-H1975 were obtained from the American Type …

Mouse transplantation model for in-vivo characterization of human tumor cells exhibits
variable and lower tumor-taking efficiency for primary human tumors than immortalized …

The green fluorescence protein (GFP) from the UBI‐GFP/BL6 transgenic line was bred into
C57BL/6J‐scid and CB‐17‐scid mice for investigating host‐tumor cell interactions. These …

Therapeutic uses of mesenchymal stromal cells (MSCs) have emerged over the past
decade. Yet, their effect on tumor growth remains highly debated, particularly in an immune …

The growth of solid tumors depends on tumor stroma. Targeting tumor stromal cells might
provide an effective strategy to inhibit tumor growth. A single adoptive transfer of CD8+ T …

Abstract Background: In 1889, Stephen Paget hypothesized that metastatic cells‐the “seeds”‐
only grow in the secondary sites‐the soil”‐with a permissive microenvironment. Here, we …

Human malignant cancer tumors grafted into nude mice produce tumors containing both
human cancer cells and the host's stromal cells. After short-term propagation of these tumors …