Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle
FM Gabhann, AS Popel - American Journal of Physiology …, 2007 - journals.physiology.org
The vascular endothelial growth factor (VEGF) family of cytokines is involved in the
maintenance of existing adult blood vessels as well as in angiogenesis, the sprouting of new …
maintenance of existing adult blood vessels as well as in angiogenesis, the sprouting of new …
Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1: a computational model
F Mac Gabhann, AS Popel - American Journal of …, 2005 - journals.physiology.org
A comprehensive, biophysically accurate, computational model of vascular endothelial
growth factor (VEGF) family member interactions with endothelial cell surface receptors was …
growth factor (VEGF) family member interactions with endothelial cell surface receptors was …
[HTML][HTML] A two-compartment model of VEGF distribution in the mouse
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …
new microvessels from existing microvasculature. Angiogenesis is a complex process …
[HTML][HTML] A compartment model of VEGF distribution in blood, healthy and diseased tissues
Background Angiogenesis is a process by which new capillaries are formed from pre-
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …
[HTML][HTML] Expression of VEGF receptors on endothelial cells in mouse skeletal muscle
PI Imoukhuede, AS Popel - 2012 - journals.plos.org
VEGFR surface localization plays a critical role in converting extracellular VEGF signaling
towards angiogenic outcomes, and the quantitative characterization of these parameters is …
towards angiogenic outcomes, and the quantitative characterization of these parameters is …
[HTML][HTML] A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse
Angiogenesis is the growth of new blood vessels from pre-existing microvessels. Peripheral
arterial disease (PAD) is caused by atherosclerosis that results in ischemia mostly in the …
arterial disease (PAD) is caused by atherosclerosis that results in ischemia mostly in the …
[HTML][HTML] Computational model of vascular endothelial growth factor spatial distribution in muscle and pro-angiogenic cell therapy
F Mac Gabhann, JW Ji, AS Popel - PLoS computational biology, 2006 - journals.plos.org
Members of the vascular endothelial growth factor (VEGF) family of proteins are critical
regulators of angiogenesis. VEGF concentration gradients are important for activation and …
regulators of angiogenesis. VEGF concentration gradients are important for activation and …
[HTML][HTML] The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
MO Stefanini, FTH Wu, F Mac Gabhann… - PLoS computational …, 2009 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise
JW Ji, F Mac Gabhann… - American Journal of …, 2007 - journals.physiology.org
VEGF is a key promoter of angiogenesis and a major target of proangiogenic therapy for
peripheral arterial disease (PAD). Greater understanding of VEGF angiogenic signaling and …
peripheral arterial disease (PAD). Greater understanding of VEGF angiogenic signaling and …
Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport
FTH Wu, MO Stefanini, F Mac Gabhann… - Physiological …, 2009 - journals.physiology.org
Vascular endothelial growth factor (VEGF) signal transduction through the cell surface
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …