The calcineurin-CRZ1 signaling pathway is conserved from yeasts to humans, and is
involved in survival, tolerance to biotic and abiotic stress conditions, virulence, and drug …

Ca2+, as a second messenger in cells, enables organisms to adapt to different
environmental stresses by rapidly sensing and responding to external stimuli. In recent …

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific
protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus …

Calcium ions are ubiquitous intracellular messengers. An increase in the cytosolic Ca2+
concentration activates many proteins, including calmodulin and the Ca2+/calmodulin …

Calcium signaling systems are widely employed in eukaryotes and are implicated in the
regulation of diverse biological processes. Calcineurin is an important signaling component …

Abstract In fungi, the Ca 2+/calcineurin signaling pathway is critical in mediating growth,
morphology, stress responses, and pathogenicity. Crz1 is a calcineurin-responsive zinc …

The calcineurin pathway is a critical signal transduction pathway in fungi that mediates
growth, morphology, stress responses, and pathogenicity. The importance of the calcineurin …

The protein phosphatase calcineurin is an important mediator connecting calcium‐
dependent signalling to various cellular responses in multiple organisms. In fungi …

Across lower eukaryotes, the transcription factor Crz1 is dephosphorylated by calcineurin,
which facilitates Crz1 translocation to the nucleus to regulate gene expression. In the fungal …

Tolerance to abiotic stresses by microorganisms require of appropriate signalling and
regulatory pathways. Calcineurin phosphatases mediate calcium‐dependent signalling …