The extracellular matrix (ECM) is composed of mixed protein fibers whose precise
composition affects biomineralization. New methods are needed to probe the interactions of …

Biological mineralization of tissues in living organisms relies on proteins that preferentially
nucleate minerals and control their growth. This process is often referred to as “templating,” …

The impact of genetics has dramatically affected our understanding of the functions of non-
collagenous proteins. Specifically, mutations and knockouts have defined their cellular …

This monograph provides a comprehensive and up-to-date approach on biomineralization.
The topical focus of the book lies on the question of how matrix proteins and cells catalyze …

The ubiquitous process of biological mineralization has preoccupied scientists for centuries.
In 1849 Quekett [1] wrote a paper entitled ''On the Intimate Structure of Bone, as Composing …

Although “chaperone molecules” rich in negatively charged residues (ie, glutamic and
aspartic acid) are known to play important roles in the biomineralization process, the precise …

Post-translational modifications are one way that biomineral-associated cells control the
function and fate of proteins. Of the ten different types of post-translational modifications, one …

Biomineralization is an inherently structural subject; the structure of the mineral phase, the
structure of the matrix composed of macromolecules and especially the structure of the …

A variety of in vitro study methods have been used to elucidate the roles of matrix molecules
in biomineralization processes. Among these, gel diffusion-precipitation studies have proved …

Bone is a hierarchically structured composite material whose basic building block is the
mineralized collagen fibril, where the collagen is the scaffold into which the hydroxyapatite …