The hippocampal mossy fiber (MF) terminal is among the largest and most complex synaptic
structures in the brain. Our understanding of the development of this morphologically …

Synapses are the key elements for signal processing and plasticity in the brain. They are
composed of nearly the same structural subelements, an apposition zone including a pre …

Synapses are the key elements for signal processing and plasticity in the brain. To
determine the structural factors underlying the unique functional properties of the …

Complete reconstructions of vertebrate neuronal circuits on the synaptic level require new
approaches. Here, serial section transmission electron microscopy was automated to …

Hippocampal slices from early postnatal rat were used to study mossy fiber (MF) growth and
synaptogenesis. The ability of MFs to form new giant synapses within isolated tissue slices …

The hippocampal mossy fiber pathway between the granule cells of the dentate gyrus and
the pyramidal cells of area CA3 has been the target of numerous scientific studies. Initially …

While hippocampal connectivity is essential to normal memory function, our knowledge of
human hippocampal circuitry is largely inferred from animal studies. Using polarized light …

Hippocampal mossy fiber boutons (hMFBs) are presynaptic terminals displaying various
forms of synaptic plasticity. The presynaptic mechanisms underlying synaptic plasticity still …

The mossy fibers (MFs) arising from dentate granule cells project primarily onto a narrow
segment of the proximal dendrites of hippocampal CA3 pyramidal cells. The mechanisms …

Synaptic transmission between hippocampal mossy fibers (MFs) and CA3 pyramidal cells
exhibits remarkable use-dependent plasticity. The underlying presynaptic mechanisms …