Liver X receptors (LXRs) are regulators of cholesterol metabolism that also modulate
immune responses. Inactivation of LXR α and β in mice leads to autoimmunity; however …

Cell signaling for T-cell growth, differentiation, and apoptosis is initiated in the cholesterol-
rich microdomains of the plasma membrane known as lipid rafts. Herein, we investigated …

High-density lipoproteins (HDLs) are heterogeneous lipoproteins that modify their
composition and functionality depending on physiological or pathological conditions. The …

T cells increase cholesterol biosynthesis upon activation to generate substrates for cellular
growth and proliferation. The ubiquitously expressed liver X receptor β (LXRβ) encoded by …

Cholesterol membrane content has a ubiquitous evolutionary f... : Current Opinion in Lipidology
Cholesterol membrane content has a ubiquitous evolutionary function in immune cell activation …

Autoimmune diseases such as systemic lupus erythematosus (SLE) are associated with
increased cardiovascular disease and reduced plasma high-density lipoprotein (HDL) …

High density lipoproteins (HDL) possess a number of physiological activities. The most
studied and, perhaps, better understood is the ability of HDL to promote excess cholesterol …

CD1 molecules are a family of major histocompatibility complex (MHC)-related glycoproteins
that present lipid and glycolipid antigens to T cells. Interestingly, it has been demonstrated …

The response of immune cells to pathogens is often associated with changes in the flux
through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to …

Excess dietary cholesterol intake and the dysregulation of cholesterol metabolism are
associated with the pathogenesis and progression of nonalcoholic fatty liver disease …