A follicular spike in cyclic AMP (cAMP) and its subsequent degradation to AMP promotes
oocyte maturation and ovulation. In vitro matured (IVM) oocytes do not receive the cAMP …

Although the oocyte is the largest cell in the body and an unavoidable phase in life, its
physiology is still poorly understood, and other cell types provide little insight into its unique …

Cyclic adenosine monophosphate (cAMP) is an important molecule in signal transduction
within the cell, functioning as a second cell messenger of gonadotrophin stimulation. The …

In mammalian ovaries, a fixed population of primordial follicles forms during the perinatal
stage and the oocytes contained within are arrested at the dictyate stage of meiotic …

Fully-grown mammalian oocytes within healthy preovulatory follicles are arrested in the first
meiotic prophase until the gonadotropins surge in vivo. However, the means by which …

Acquisition of oocyte developmental competence needs to be understood to improve clinical
outcomes of assisted reproduction. The stimulation of cumulus cell concentration of cyclic …

The relationship between cAMP and the capacity of two partially-purified fractions of porcine
follicular fluid (PFF) to suppress mouse oocyte maturation was investigated. The fractions …

Oocyte in vitro maturation (IVM) is an important assisted reproductive technology and
research tool. The adoption of IVM into routine clinical practice has been hindered by its …

Cumulus cells sustain the development and fertilization of the mammalian oocyte. These
cells are retained around the oocyte by a hyaluronan-rich extracellular matrix synthesized …

Cyclic AMP (cAMP) is one of the key regulators of the resumption of oocyte meiosis (oocyte
maturation) in several mammalian species. In this study we have examined the role for …