Background and Purpose Acyl derivatives of CoA have been shown to act as antagonists at
human platelet and recombinant P2Y1 receptors, but little is known about their effects in the …

Palmitoyl CoA (PaCoA) is an antagonist at human recombinant P2Y1 purine receptors
(Coddou et al., 2003), HEK cells, human platelets (Manolopoulos et al., 2008), and rat …

Agonist and antagonist effects of the putative P2Y1 receptor antagonist adenosine 3′-
phosphate 5′-phosphosulphate (PAPS) were studied in intact tissues. In the carbachol …

The action of the putative P2Y1-receptor antagonist pyridoxalphosphate-6-azophenyl-2', 4'-
disulphonic acid (PPADS) was studied in guinea pig aorta for potential use in the …

Vasorelaxation and hyperpolarization of endothelial cells by adenosine 5′‐[β‐thio]
diphosphate (ADPβS) and adenosine 5′‐[γ‐thio] triphosphate (ATPγS) were studied in rat …

Background and Purpose There is a lack of potent, selective antagonists at most subtypes of
P2Y receptor. The aims of this study were to characterise the pharmacological properties of …

In this study, we have investigated the mechanism of ADP‐induced relaxation of porcine
coronary artery (PCA) rings. The P2Y receptor agonists ADP and ADPβS produced …

We have performed a detailed investigation of the effects on platelet function of coenzyme A
(CoA) and several acyl-CoAs. Platelet aggregation was measured by turbidimetry and by …

Based on pharmacological criteria, we previously suggested that in the mouse aorta,
endothelium‐dependent relaxation by nucleotides is mediated by P2Y1 (adenosine …

1 The endothelium‐dependent relaxation of blood vessels induced by P2Y‐purinoceptor
activation has often been shown to involve prostacyclin and/or nitric oxide (NO) release. In …