Effect of aging in human cortical pre-and postsynaptic serotonin binding sites
A Eriksson, E Mellerup, P Plenge, J Marcusson - Brain research, 1993 - Elsevier
HT 1A, 5-HT 1D, 5-HT 2 binding sites and affinity and 5-HT uptake sites were simultaneously
determined in frontal cortex samples from 23 control subjects, aged 16–75 years. A …
determined in frontal cortex samples from 23 control subjects, aged 16–75 years. A …
Activators of protein kinase C decrease serotonin transport in human platelets
GM Anderson, WC Horne - Biochimica et Biophysica Acta (BBA)-Molecular …, 1992 - Elsevier
Abstract Treatment of human platelets with activators of protein kinase C (PKC) for 5–20 min
resulted in substantial reductions in the rate of platelet serotonin (5-HT) transport. The mean …
resulted in substantial reductions in the rate of platelet serotonin (5-HT) transport. The mean …
Effects of reduced endogenous 5‐HT on the in vivo binding of the serotonin transporter radioligand 11C‐DASB in healthy humans
PS Talbot, WG Frankle, DR Hwang, Y Huang… - Synapse, 2005 - Wiley Online Library
Abstract Although abnormal serotonin (5‐HT) function is implicated in a range of mental
disorders, there is currently no method to directly assess 5‐HT synaptic levels in the living …
disorders, there is currently no method to directly assess 5‐HT synaptic levels in the living …
Effects of estrogen and testosterone treatment on serotonin transporter binding in the brain of surgically postmenopausal women–a PET study
H Jovanovic, L Kocoska-Maras, AF Rådestad… - Neuroimage, 2015 - Elsevier
Sex hormones and the serotonergic system interact in the regulation of mood, learning,
memory and sexual behaviour. However, the mechanisms have not been fully explored. The …
memory and sexual behaviour. However, the mechanisms have not been fully explored. The …
Affinity modulation of [3H] imipramine,[3H] paroxetine and [3H] citalopram binding to the 5-HT transporter from brain and platelets
P Plenge, ET Mellerup, H Laursen - European Journal of Pharmacology …, 1991 - Elsevier
The dissociations of [3 H] imipramine,[3 H] paroxetine and [3 H] citalopram from the 5-HT
(serotonin 5-hydroxytryptamine) transporter were found to be markedly influenced by …
(serotonin 5-hydroxytryptamine) transporter were found to be markedly influenced by …
Binding of some antidepressants to the 5-hydroxytryptamine transporter in brain and platelets
JO Marcusson, SB Ross - Psychopharmacology, 1990 - Springer
Antidepressant agents with properties to inhibit 5-hydroxytryptamine (5-HT, serotonin)
uptake in brain tissue and platelets bind with high affinities to neuronal and platelet …
uptake in brain tissue and platelets bind with high affinities to neuronal and platelet …
[11C]MADAM, a new serotonin transporter radioligand characterized in the monkey brain by PET
C Halldin, J Lundberg, J Sóvágó, B Gulyás… - Synapse, 2005 - Wiley Online Library
The aim of this study was to explore the potential of a new selective serotonin transporter (5‐
HTT) inhibitor, N, N‐dimethyl‐2‐(2‐amino‐4‐methylphenylthio) benzylamine (MADAM, Ki …
HTT) inhibitor, N, N‐dimethyl‐2‐(2‐amino‐4‐methylphenylthio) benzylamine (MADAM, Ki …
Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination?
The serotonin transporter (SERT) has been implicated in a variety of neuropsychiatric
disorders including depression, schizophrenia, substance abuse, alcoholism, and …
disorders including depression, schizophrenia, substance abuse, alcoholism, and …
Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C] DASB
WG Frankle, R Narendran, Y Huang, DR Hwang… - Biological …, 2005 - Elsevier
BACKGROUND: Postmortem studies have reported several alterations in serotonin
transporter (SERT) binding parameters in patients with schizophrenia. The aim of this study …
transporter (SERT) binding parameters in patients with schizophrenia. The aim of this study …
Comparison of [3H] paroxetine and [3H] cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain
EV Gurevich, JN Joyce - Neuropsychopharmacology, 1996 - Elsevier
Previous studies have demonstrated that [3H] paroxetine and [3H] cyanoimipramine ([3H]
CN-IMI) are highly selective ligands for the serotonin (5-HT) transporter. Using membrane …
CN-IMI) are highly selective ligands for the serotonin (5-HT) transporter. Using membrane …