Background Squamous cell carcinoma (SCC) of the skin is a common form of nonmelanoma
skin cancer. Monocyte chemotactic protein 1-induced protein 1 (MCPIP1), also called …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common form of cancer
worldwide. One frequent alteration found in this type of cancer is overactivation of the …

Flaky skin (fsn) is an autosomal recessive mouse mutation with papulosquamous disease
features similar to human psorasis. In fsn/fsn skin, one sees marked acanthosis and …

Carcinogenesis involves the accumulation of genetic changes within a single cell. Tumor
promotion functions in the initial clonal expansion of an initiated cell but is generally not …

Cutaneous squamous cell carcinoma (cSCC) ranks second in the frequency of all skin
cancers. The balance between keratinocyte proliferation and differentiation is disrupted in …

Interaction of cells with the basement membrane is important for cell proliferation and
differentiation. Disruption of the basement membrane is an early event during progression of …

Polycyclic aromatic hydrocarbon (PAH) DNA adducts have been associated with
carcinogenesis, which is accompanied by multiple alterations in gene expression. We used …

All-trans retinoic acid (RA), the principle biologically active form of vitamin A, is essential for
many developmental process as well as homeostasis in the adult. Many lines of evidence …

The use of animals models of human cancers has proved useful in the elucidation of
molecular events which occur during tumour development. Mouse skin has been used as a …

Keratins have been demonstrated to be suitable markers of changes taking place during
epithelial neoplasia. Therefore, we analyzed 18 mouse skin tumors (nine papillomas and …