Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy

A Buqué, N Bloy, F Aranda, I Cremer… - …, 2016 - Taylor & Francis
… at assessing the therapeutic profile of aspirin and celecoxib, … -driven cervical cancer, breast
carcinoma and glioma, … these molecules in cancer patients are Phase I/II trials, perhaps …

MicroRNA and cyclooxygenase-2 in breast cancer

W Li, Z Zhang, B Wang, N Liang, Q Zhou, S Long - Clinica Chimica Acta, 2021 - Elsevier
… acts on the tumor microenvironment to increase the production of … The COX-2 inhibitor
celecoxib enhanced the efficacy of … cancers because it has a potential as a disease biomarker and …

[HTML][HTML] Inflammatory microenvironment in the initiation and progression of bladder cancer

X Sui, L Lei, L Chen, T Xie, X Li - Oncotarget, 2017 - ncbi.nlm.nih.gov
… certain cancers such as cervical, anogenital, oropharyngeal … Celecoxib, a cyclooxygenase-2
(COX-2) inhibitor, promotes … chronic inflammation in tumor microenvironment will hopefully …

[HTML][HTML] Molecular markers to predict prognosis and treatment response in uterine cervical cancer

M Fleischmann, G Chatzikonstantinou, E Fokas… - Cancers, 2021 - mdpi.com
… of an immunosuppressive tumor microenvironment (TME) by … trial, a phase I-II study testing
the COX-2 inhibitor celecoxib … to secrete cyclooxygenase 2 (COX-2) and induce cancer stem …

[HTML][HTML] The role of tumor microenvironment in resistance to anti-angiogenic therapy

S Ma, S Pradeep, W Hu, D Zhang, R Coleman… - …, 2018 - ncbi.nlm.nih.gov
… in EPCs are a potential biomarker of sorafenib efficacy 120 . … a selective cyclooxygenase-2
(COX2) inhibitor (celecoxib) … in phase I/II clinical testing in patients with breast cancer 165 . …

… of etoricoxib during concurrent chemo-radiation of cervical cancer patients could result in faster resolution of gross disease: a prospective single-institution study

SS Dhar, UP Shahi, D Kumar, R Mishra… - Indian Journal of …, 2020 - Springer
Cyclooxygenase-2 inhibitor studies in animal models have thrown light on its role in … %,
respectively, in cervical cancer patients receiving chemo-radiotherapy treated with celecoxib [20] …

[HTML][HTML] Phase IIa Clinical Biomarker Trial of Dietary Arginine Restriction and Aspirin in Colorectal Cancer Patients

JA Zell, TH Taylor, CG Albers, JC Carmichael… - Cancers, 2023 - mdpi.com
… of the microbiome and the tumor microenvironment [9]. … skin cancer, melanoma in situ,
Stage I cervical cancer, or … III colon cancer patients to a 3 year intervention of celecoxib or …

[HTML][HTML] Breaking Barriers: Modulation of Tumor Microenvironment to Enhance Bacillus Calmette–Guérin Immunotherapy of Bladder Cancer

OM Ibrahim, P Kalinski - Cells, 2024 - mdpi.com
evaluation of durvalumab is taking place in the phase I/II … following BCG treatment, and
cyclooxygenase-2 (COX2) has … clinical trials involving systemic blockade of COX2 (oral celecoxib)…

[HTML][HTML] Anti-inflammatory drugs as anticancer agents

S Zappavigna, AM Cossu, A Grimaldi… - International journal of …, 2020 - mdpi.com
… ), are able to interfere with tumor microenvironment by reducing cell … of the STAT3 pathway
in cervical cancer. Together, the … FAP patients that used a specific COX-2 inhibitor, celecoxib, …

Targeting the PI3K/AKT/mTOR pathway in biliary tract cancers: A review of current evidences and future perspectives

F Corti, F Nichetti, A Raimondi, M Niger, N Prinzi… - Cancer treatment …, 2019 - Elsevier
… Carcinogenic stimuli of the tumor microenvironment promote … Cyclo-Oxigenase 2 inhibitor
celecoxib has been evaluated … solid tumors refractory to standard therapy (cohort I/II), …