… Benign prostatic hyperplasia (BPH) is a highly prevalent disorder … aorta, while prazosin
exerted a similar affinity in both tissues, … high affinity for prazosin, indicative of the α 1A -subtype. …

… 1L -adrenoceptor subtype, having a lower affinity for prazosin … in patients with benign prostatic
hypertrophy is contraction of … Comparative alpha-1 adrenoceptor subtype selectivity and …

… for the treatment of benign prostatic hypertrophy, alfuzosin, … only low affinity for prazosin or
bunazosin but high affinity for … long term selective alpha-1 adrenoceptor blockade? Neurolurol …

… Benign prostatic hyperplasia is a hormone-dependent … the binding affinity for the animal and
human alpha-1 AR subtypes of … The relatively low affinity exhibited by prazosin and the other …

… of selective alpha-1 and alpha-2 ligands, [3H]prazosin and [3H]-… was saturable and of high
affinity. Scatchard analysis produced … of alpha-1 and alpha-2 adrenoceptors to specific human …

… retention secondary to benign prostatic hyperplasia (BPH). … affinity for D 3 and 5-HT 1A
receptors is probably too low for … of [ 3 H]-prazosin to the three subtypes of human α 1 -AR by …

… , a markedly lower incidence of adverse effects with prazosin in … prazosin and has a high in
vitro affinity for ai-adrenoceptors … of the alpha1-blocker doxazosin in the treatment of benign …

… of alpha 1-AR mRNA expression in ‘normal’ prostate tissue … is a low prazosin affinity variant
of the alpha 1A-AR subtype. [… sympathetic activity and prostatic hyperplasia seen in animal …

… with human α 1A , α 1B or α 1D subtype using [ 3 H] prazosin … it exhibits greater affinity for
the α 1A -adrenoceptor subtype (… urinary tract, and peripheral vascular tissues, comparative in …

… prazosin and urapidil showed similar affinity to [3H]-prazosin … outlet obstruction seen in benign
prostatic hypertrophy (BPH). … Characterization of alpha-1 adrenergic receptors in the heart …