Evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management of patients with spasticity due to multiple sclerosis

UK Zettl, P Rommer, P Hipp… - Therapeutic advances in …, 2016 - journals.sagepub.com
… , open-label extension study to provide safety and tolerability information on the long-term
use of THC-CBD, a total of 146 patientsopioid-refractory pain, THC-CBD spray was given as …

Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases

M Darkovska-Serafimovska, T Serafimovska… - … of pain research, 2018 - Taylor & Francis
… ; and analgesic effects in the treatment of cancer-related pain … The study showed that
the long-term use of THC/CBD spray is … open-label extension study to investigate the long-term

… trial of medical cannabis in patients with stage IV cancers to assess feasibility, dose requirements, impact on pain and opioid use, safety, and overall patient …

DM Zylla, J Eklund, G Gilmore, A Gavenda… - Supportive Care in …, 2021 - Springer
… goals and tolerance. Dispensaries provided records of all … with a specific THC/CBD dose.
The mean, median, and range at … in non-cancer-related pain [16], we analyzed pain and total …

[HTML][HTML] A scoping review on clinical trials of pain reduction with cannabis administration in adults

R Haleem, R Wright - Journal of clinical medicine research, 2020 - ncbi.nlm.nih.gov
… is a cannabis extract containing fixed doses of THC-CBD, THC or … , oral spray) in 43 patients
with cancer-related pain and … Most non-randomized trials were single-arm, open-label with …

An update of current cannabis-based pharmaceuticals in pain medicine

I Urits, M Borchart, M Hasegawa, J Kochanski… - Pain and Therapy, 2019 - Springer
… associated with long-term opioid use or pain refractory to opioid therapy. … use of THC/CBD
oromucosal spray has also been considered as treatment for non-cancer-related chronic pain

Practical Considerations for the Use of Cannabis in Cancer Pain Management—What a Medical Oncologist Should Know

A Gorzo, A Havași, Ș Spînu, A Oprea, C Burz… - Journal of Clinical …, 2022 - mdpi.com
… Up to 40% of the patients with cancer-related pain have neuropathic … A long-term observational
study conducted in Israel … (producing effective pain management with tolerable adverse …

Opioid analgesics for nociceptive cancer pain: A comprehensive review

C Abdel Shaheed, C Hayes, CG Maher… - CA: A Cancer …, 2024 - Wiley Online Library
pain), whereas one was an openlabel trial in 174 people that … [THC], cannabidiol [CBD],
THC:CBD combinations, THC … with cancerrelated pain,272 and opioid‐related deaths in …

Role of cannabidiol for improvement of the quality of life in cancer patients: potential and challenges

R Green, R Khalil, SS Mohapatra… - International Journal of …, 2022 - mdpi.com
… its effectiveness to alleviate cancer-related pain [79]. This study was open-label with a self-…
In patients with pain due to spinal cord injury, oral THC/CBD self-administered up to 130 mg/…

Cannabinoid formulations and delivery systems: Current and future options to treat pain

B Stella, F Baratta, C Della Pepa, S Arpicco, D Gastaldi… - Drugs, 2021 - Springer
… , including chronic and cancer-related pain, the nausea and … forms of short- and long-term
synaptic plasticity. In addition, … to include cannabis-based medications and explore the wide …

[HTML][HTML] Cannabinoids and pain: new insights from old molecules

S Vučković, D Srebro, KS Vujović, Č Vučetić… - Frontiers in …, 2018 - frontiersin.org
… for the treatment of cancer-related pain. Currently, it is in phase 3 trials for cancer … open-label
extension study of 43 patients with long-term use of the THC:CBD oromucosal spray