Monoclonal antibody therapeutics and apoptosis

DL Ludwig, DS Pereira, Z Zhu, DJ Hicklin, P Bohlen - Oncogene, 2003 - nature.com
… such as Bcl-2 and inhibitor of apoptosis (IAPs) participate in the … for tumor-targeted cell killing
through apoptosis and its … , the antitumor activity in vivo is most likely due to an inhibition of …

Preparation and characterization of novel chitosan–protamine nanoparticles for nucleus-targeted anticancer drug delivery

X Yu, J Hou, Y Shi, C Su, L Zhao - International Journal of …, 2016 - Taylor & Francis
… of inhibitors of apoptosis (IAPs) in combination with tumor-targeted delivery of tumor
necrosis factor-α leads to synergistic antitumor activityCancer Gene Ther2013201465623154431 …

Fully human targeted cytotoxic fusion proteins: new anticancer agents on the horizon

UH Weidle, G Georges… - Cancer genomics & …, 2012 - cgp.iiarjournals.org
… PI-9, resulting in blocking of their enzymatic activity (51). The … (IAPs) and survivin (67).
Plasmid-driven expression of fusion … displayed enhanced stability and antitumoral activity (107). A …

Targeting death-inducing receptors in cancer therapy

K Takeda, J Stagg, H Yagita, K Okumura, MJ Smyth - Oncogene, 2007 - nature.com
Inhibitor of apoptosis proteins (IAPs) can attenuate the … The MD5-1-induced antitumor
effect was demonstrated to … cells with both interferon-γ and retinoic acid resulted in synergistic

Apoptosis-inducing TNF superfamily ligands for cancer therapy

OA Diaz Arguello, HJ Haisma - Cancers, 2021 - mdpi.com
… These factors impede the inhibitor of apoptosis proteins (IAPs… checkpoint inhibitors (ICIs)
while enhancing their antitumor effect [… them in combination with other anticancer therapeutics. …

[HTML][HTML] Evolving strategies and application of proteins and peptide therapeutics in cancer treatment

AG Mukherjee, UR Wanjari, AV Gopalakrishnan… - Biomedicine & …, 2023 - Elsevier
… and other indicators uniquely linked with or overexpressed on tumors compared to …
synergistic benefits. One example of this new area is the use of anticancer peptides in combination

AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas

TL Smith, Z Yuan, M Cardó-Vila… - Proceedings of the …, 2016 - National Acad Sciences
… Indeed, combining the functional attributes of prokaryotic … within permeabilized NET cells
was due to internalized Oct-… After washing and blocking, the cells were incubated with 10 9 …

[HTML][HTML] Nanodrug Delivery Systems in Antitumor Immunotherapy

Z Guo, J Ye, X Cheng, T Wang, Y Zhang… - Biomaterials …, 2024 - spj.science.org
… proteins (IAP) antagonist AZD5582 without severe toxic side effects. Huang et al., Guo et al.,
… its tumor targeted fluorescence turn-on imaging, and the synergistic antitumor effect caused …

Effective gene–virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5

XY Liu, SB Qiu, WG Zou, ZF Pei, JF Gu, CX Luo… - Molecular Therapy, 2005 - cell.com
tumor with ZD55-hTRAIL resulted in dramatic inhibition of … This strong anti-tumor activity
was due to the fact that two … vectors has exerted synergic or compensatory anti-tumor activity [ …

Bacteriophage‐mediated therapy of chondrosarcoma by selective delivery of the tumor necrosis factor alpha (TNFα) gene

A Chongchai, S Waramit, K Suwan… - The FASEB …, 2021 - Wiley Online Library
… sequence for the human tumor necrosis factor- α (TNFα) as a … Next, to further validate the
anti- tumor effect of RGD4C/ H5W… improved version of a tumor- targeted phage carrying TNFα, …