… In Lewy body disease -synuclein is incorporated within Lewy … J, Jakes R: Alpha-synuclein
binds to tau and stimulates the … mer’s -amyloid fibril formation in vitro. Exp Neurol 2006; 202: …

… as opposed to Alzheimer’s Disease (AD), in which in vivo investigations using radiotracers …
recombinant α-syn protein, forming amyloid fibrils which enhance fluorescence of thioflavin T (…

… We used several markers of the endocytic pathway fused to the enhanced green fluorescent
protein (EGFP) to determine the mechanisms by which neurons and astrocytes processed …

… the Alzheimer's disease, dementia with Lewy bodies-Aβ, pure dementia with Lewy bodies
… Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via …

… presence of intraneuronal inclusions called Lewy bodies (LBs) and Lewy neurites (LNs), …
increases with age. Epidemiological studies have demonstrated that the risk of PD increases …

… vitro seed amplification assays (SAA) detecting misfolded alpha-synuclein (αSyn) in cerebrospinal
fluid (… Alzheimer's disease (AD), is characterized by the misfolding and aggregation of …

… The emerging field of cerebrospinal fluid and molecular imaging … of dementia in LBD and
include studies that have used in vivo … disease and AD co-pathology, may increase the risk of …

… hallmarks of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), while glial …
into WT mice in vivo. We hypothesized that enhancing neuronal activity would significantly …

… The determinantal consequences of altered nuclear aSyn content is particularly evident
from in-vivo studies, where enhanced aSyn Nuc levels results in the loss of dopaminergic …

… increase in the levels of soluble oligomers of α-syn in the DLB brains compared to those with
Alzheimer's disease … -1 epitope on in vitro formed α-syn oligomers and fibrils by subjecting …