… these rats are extremely insulin resistant and hyperinsulinemic as … that the antihypertensive
effects of chronic mibefradil treatment are … Chronic T-type calcium channel blockade in …

… In the current study, mibefradil treatment in insulin-resistant … Since mibefradil inhibits T-type
and L-type Ca 2+ channels, it … Mibefradil, as a calcium channel blocker, inhibits the release …

… in β-cells can be regulated under the peripheral insulin resistant conditions. It has been …
applying T-type calcium channel siRNA, or channel blockers (eg mibefradil, NNC 55-0396) to rat …

… potassium channel complex (Persistent Hyperinsulinemic … The Ttype calcium channel
blocker, mibefradil (Fig. 11) has … insulin-resistant, obese patients with mild hypertension, but …

… high, suggesting that the rats were insulin-resistant. A rise in … Our results demonstrate that
chronic fructose feeding in rats … blockade blunts hyperinsulinemia-induced hypertension in …

… hypertensive rat (FHR) and a chronically insulin treated rat. In … hyperinsulinemia, insulin
resistance and hypertension in … hypertension that are hyperinsulinemic and insulin resistant, …

… a calcium channel blocker which blocks the L-type, T-type and N-type of calcium channels
… Its peak plasma levels appear 2 - 4 h after oral administration, when given chronically it has …

… that is associated with insulin resistance, hyperinsulinemia, hyperglycaemia,
hypercholesterolaemia and hypertriglyceridaemia. We have examined the effect of chronic …

… by obesity, hyperlipidemia and hyperinsulinemia. This cluster is … Conversely, blockade of
AT 1 receptors in insulin-resistant … Long-term reflex excitation of the SNS can be induced by …

… with hypertension are insulin-resistant or have hyperinsulinemia,… of long-term (frequently
lifetime) antihypertensive therapy … , and other CCAs (including T-type CCAs), such as mibefradil, …