Functional analysis of a voltage‐gated sodium channel and its splice variant from rat dorsal root ganglia

PS Dietrich, JG McGivern, SG Delgado… - Journal of …, 1998 - Wiley Online Library
… the identification of the channels listed above, our unganglia—Xenopus oocyte—… rBII/IIa
(Patton and Goldin, … MD (1997) Effects of clamp rise-time on rat brain hA sodium gated Na* …

Meperidine and Lidocaine Block of Recombinant Voltage-Dependent Na+Channels  Evidence that Meperidine is a Local Anesthetic

LE Wagner, M Eaton, SS Sabnis… - The Journal of the …, 1999 - pubs.asahq.org
… electrode coupling and speed clamp rise time. Typical charging … ion channel pore. 37Recently,
critical amino acid residues affecting LA block in expressed rat brain IIA Na + channels

A sodium channel mutation causing epilepsy in man exhibits subtle defects in fast inactivation and activation in vitro

AK Alekov, MM Rahman, N Mitrovic… - The Journal of …, 2000 - Wiley Online Library
… tsA201 cell line using the whole-cell patch clamp technique. … A, 10-90% rise time of the
sodium current as a function of test … studied in the rat brain IIa sodium channel for other purposes, …

A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A

DK Rabert, BD Koch, M Ilnicka, RA Obernolte… - Pain, 1998 - Elsevier
… studied using two electrode voltage clamp. Injection of 3 ng of … 2 ng hPN3 cRNA had no
effect upon the inactivation kinetics or … of rat IIA sodium channels expressed in Xenopus oocytes

Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function

Y He, A Benz, T Fu, M Wang, DF Covey, CF Zorumski… - …, 2002 - Elsevier
… Miniature IPSC peak amplitude, rise time and frequency … Two-electrode voltage clamp of
Xenopus oocytes expressing … of the ligand-gated ion channel superfamily in terms of the large …

Voltage gated ion channels: targets for anticonvulsant drugs

AC Errington, T Stohr, G Lees - Current topics in medicinal …, 2005 - ingentaconnect.com
… II and IIA sodium channels expressed in the Xenopus oocyte … OAG can reduce sodium currents
in voltage clamped N1E-… have little effect upon single spikes or the duration or rise time of …

Voltage-dependent inhibition of RCK1 K+ channels by phenol, p-cresol, and benzyl alcohol

AA Elliott, JR Elliott - Molecular pharmacology, 1997 - ASPET
clamp. Zamponi and French (8) reported a much greater block by phenol of cardiac sodium
channels … dependence and effect (or lack of effect) on the 10–90% rise time. ×, control …

Molecular basis of functional diversity of voltage‐gated potassium channels in mammalian brain.

W Stühmer, JP Ruppersberg, KH Schröter… - The EMBO …, 1989 - embopress.org
… similarto the transmitter-gated ion channels. Members of this … dRefers to rise time of ensemble
patch currents in ms. It was … A two-microelectrode voltage clamp was used to test for the …

On the Molecular Nature of the Lidocaine Receptor of Cardiac Na+ Channels: Modification of Block by Alterations in the α-Subunit III-IV Interdomain

PB Bennett, C Valenzuela, LQ Chen… - Circulation research, 1995 - Am Heart Assoc
channels in Xenopus oocytes, we minimized endogenous … to minimize electrode coupling
and to speed the clamp rise time. … effect of lidocaine being on preopen activated or open Na + …

A functional null mutation of SCN1B in a patient with Dravet syndrome

GA Patino, LRF Claes, LF Lopez-Santiago… - Journal of …, 2009 - Soc Neuroscience
… AP rise time was calculated as the change in time from the … by Na v 1.1 and Na v 1.2 using
the whole-cell patch-clamp … subunits with sodium channel α subunits in Xenopus oocytes. This …