… , and function of peripheral opioid receptors, the production and release of opioid peptides
in peripheral inflamed tissue, implications for analgesia and opioid tolerance, therapeutic …

… antinociceptive effects of their ligands in inflammatory pain [30]. … opioid peptides using the
intraarticularly injected opioid antagonist naloxone [36]. Immunederived endogenous opioids …

… Here we examine peripheral antinociception elicited by … -releasing factor (CRF)-induced
antinociception. To this end, we … this effect is mediated by peripheral opioid receptors. This is …

… to mediate peripheral antinociception in noninflamed … opioid peptides in immune cells. A
further interesting question is whether immune-derived opioid peptides and exogenous opioids …

… These activate peripheral opioid receptors and produce antinociception (analgesia) by inhibiting
… Immune-derived opioid peptides apparently play a substantial role in the modulation of …

… understanding of the peripheral actions of the … opioids, 6 and (ii) inflammation to stimulate
delivery of opioid receptors to the site of insult, and hence produce a degree of antinociception. …

… of opioid analgesia in peripheral tissue. Notwithstanding the traditional view that opioid
antinociception … nervous system, there are peripheral opioid receptors that mediate analgesic …

… of cell activation in immune-derived opioid antinociception. The recovery of CRF-induced …
relationship for immune-derived opioids or perhaps even a limit of cell infiltration kinetics. …

… In contrast to the modulation of opioid antinociception by … opioid-induced lethality (suggesting
no alterations in opioid-… the effects of immune-derived EOPs at central or peripheral levels (…

… that opioid antinociception is mediated exclusively within the central nervous system, peripheral
opioid … nerve activity at the peripheral end by immune-derived opioid peptides. Thus, the …