… of Candida albicans N-myristoyltransferase complexes with … in mammal cells, selective
inhibitors against fungal Nmts are … This peptide mimetic inhibitor was designed based on the …

… of the myristoyl group of myristoyl-CoA to the N-terminal … of NMT inhibitors that have been
reported (a) peptidomimetic … docking was validated with bound peptidic inhibitor (MIM) to …

… of myristoyl CoA to the N-terminal glycine of eukaryotic cellular … Although several
peptidomimetic inhibitors of C. … novel non-peptidic Nmt inhibitors having strong antifungal activity. …

… to determine whether myristoyl-CoA:protein N-myristoyltransferase (Nmt) … New ways of
treating cryptococcal meningitis are needed given the … -selective peptidomimetic inhibitors (Refs. …

… Antifungal peptide selectivity is dependent upon a precise … A peptidomimetic is a small
protein-like chain designed to … such as Candida albicans require N-myristoyltransferase (NMT) for …

… enzyme myristoyl CoA: protein N-myristoyltransferase (NMT) … achieved by peptidomimetic
protease inhibitors. Consequently, … to potent inhibition, perhaps an indication that the peptide-…

… Nmt is a target for anti-viral and anti-fungal therapy. Perturbing N-… protein substrate
specificities of fungal and human Nmts have been exploited to develop species-selective inhibitors …

… , including the fungi Candida albicans and Cryptococcus … observations, peptide-based
and peptidomimetic inhibitors have … In vitro studies using four antifungal compounds have …

… MyristoylCoA:protein N-myristoyltransferase (NMT) covalently attaches the 14-carbon … for
development of selective fungicidal inhibitors. This difference in peptide specificity has recently …

… The structure reveals how Nmt’s myristoyl-CoA and peptide … The enzyme is highly selective
for myristoyl-CoA in vitro and … cerevisiae as well as Candida albicans and Cryptococcus …