… growing oocytes and females are infertile. There is no effect … , molecular genetic, and structural
aspects of mouse ZP genes … Furthermore, specific single mutations in the ZP domain can …

… In mice, the targeted knockout of either the gene encoding ZP2 … We detected a homozygous
frameshift mutation in ZP1 in six … this mutation prevents the formation of the zona pellucida …

… In this study, we have established a mouse model in which … zona pellucida (ZP) as a female
factor, are involved in fertility … of infertile men, although mutations in the proacrosin gene of …

… contributed to the research on wild-type and mutant mice carried out in our laboratory at
the Roche Institute of Molecular Biology and Mount Sinai Medical School. Our research was …

… are unable to construct a ZP, ovulate few if any eggs, and are infertile. ZP1–3 have a … Mutations
in genes encoding ZPD proteins can result in severe human … Molecular biology of the cell …

… infertile, while the corresponding 236 mutant mice were fertile.The different phenotypes of
the same gene mutation of 237 zona pellucida in human and mouse … 627 Molecular Genetics …

… for male fertility comes from studies of mouse models. Targeted gene disruption strategies
in mice have revealed hundreds of genes causing abnormal spermatogenesis and/or fertility …

… of Zp1-null mice, in which a zona pellucida is formed, … zona pellucida, we have established
mouse lines that lack ZP2 and compared the effects of each (Zp1, Zp2 and Zp3) null mutation …

… Zp2 null female mice formed a thin ZP and were infertile [6]. Zp3 null female … mutation and
will facilitate the genetic diagnosis of infertile individuals with abnormal ZP and female infertility…

… Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are
infertile… of eggs lacking a zona pellucida and infertility in female mice. Proc Natl Acad Sci …