Testing for inactivation of pertussis toxin and reversion to toxicity in aP vaccines has
historically relied on the murine histamine sensitization test, that lacks mechanistic …

A binding assay was recently published that differentiates between pertussis toxin (PTx) and
the pertussis toxoid (PTd) used in acellular pertussis vaccines based on the selective …

The histamine sensitization test (HIST) is a lethal test for batch release of acellular pertussis
or its combination vaccines (ACV). Large numbers of animals have been used and it is …

The current test of acellular Bordetella pertussis (aP) vaccines for residual pertussis toxin
(PTx) is the Histamine Sensitization test (HIST), based on the empirical finding that PTx …

Whooping cough is caused by the bacterium Bordetella pertussis. There are currently two
types of vaccines that can prevent the disease; whole cell vaccines (WCV) and acellular …

As an extension of the BSP076 study (see the article'Collaborative Study for the
Standardisation of the Histamine Sensitizing Test in Mice and the CHO Cell-based Assay for …

Speculation that the Japanese modified intra-cerebral challenge assay, which is used in
several countries for control of acellular pertussis vaccines, depends on the presence of …

A collaborative study has been carried out to establish the precision and accuracy of five test
systems for the assessment of the toxicity of whole cell pertussis vaccine. To this end, six …

Abstract The 'International Workshop on Alternatives to the Murine Histamine Sensitization
Test for Acellular Pertussis Vaccines: Progress and Challenges in the Replacement of …

Specific toxicity test is a major quality control test for acellular pertussis (aP) vaccines
performed by manufacturers and regulatory authorities. The 'mouse body weight gain test …