[HTML][HTML] RNA-targeted therapies and high-throughput screening methods
S Zhu, S Rooney, G Michlewski - International Journal of Molecular …, 2020 - mdpi.com
… adeno-associated virus (AAV) intravenously, facilitating the … potential drug enhances full-length
SMN protein production … by a fluorescent structural probe 2-aminopurine [106]. Nineteen …
SMN protein production … by a fluorescent structural probe 2-aminopurine [106]. Nineteen …
[HTML][HTML] Novel therapeutics for Epstein–Barr virus
G Andrei, E Trompet, R Snoeck - Molecules, 2019 - mdpi.com
… treated with corticosteroids [75]. Following these findings, HCMV trials were suspended but
adenovirus … Structure-activity relationships of (S,Z)-2-aminopurine methylenecyclopropane …
adenovirus … Structure-activity relationships of (S,Z)-2-aminopurine methylenecyclopropane …
Application of conditionally replicating adenoviruses in tumor early diagnosis technology, gene-radiation therapy and chemotherapy
… that using chemical drugs to prevent cancer cell … drugs in common use, and new chemical
drugs are continuing to be developed. However, there are a lot of side effects with these drugs. …
drugs are continuing to be developed. However, there are a lot of side effects with these drugs. …
[HTML][HTML] Inhibitors of DNA glycosylases as prospective drugs
GV Mechetin, AV Endutkin, EA Diatlova… - International Journal of …, 2020 - mdpi.com
… must be blocked by mutations or another drug used in combination with a BER inhibitor. The
… , uracil analogs used as drugs or prodrugs, or oxidized purines appearing through MTH1 …
… , uracil analogs used as drugs or prodrugs, or oxidized purines appearing through MTH1 …
[HTML][HTML] PKR: a kinase to remember
S Gal-Ben-Ari, I Barrera, M Ehrlich… - Frontiers in molecular …, 2019 - frontiersin.org
… rate limiting step of protein synthesis. Phosphorylation of eIF2α … Specifically, adenovirus and
Epstein-Barr virus transcribe … pharmacological inhibitor of PKR is the 2-aminopurine (2-AP) …
Epstein-Barr virus transcribe … pharmacological inhibitor of PKR is the 2-aminopurine (2-AP) …
[HTML][HTML] Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger–containing 1 (UHRF1) for anti-cancer drug development
… (ICL) that result when cells are treated with DNA damaging … a site-selective monitoring study
using 2-aminopurine (2-Ap), … that acts by inhibition of protein synthesis and has the ability …
using 2-aminopurine (2-Ap), … that acts by inhibition of protein synthesis and has the ability …
eIF2α Phosphorylation Mediates IL24-induced Apoptosis through Inhibition of Translation
… inhibitory effect of IL24 on protein synthesis and cell growth. … lysates from squamous cell
carcinoma cells treated with IL24 or … presence of PKR inhibitor 2-aminopurine or PERK inhibitor, …
carcinoma cells treated with IL24 or … presence of PKR inhibitor 2-aminopurine or PERK inhibitor, …
Modulation of radiation-induced apoptosis
ST Palayoor, RE Langley, CN Coleman… - …, 2021 - taylorfrancis.com
… One of the molecular targets of caffeine and 2-aminopurine … as a protein that binds to
adenovirus EIB 19-kDa protein as well … dependent on RNA or protein synthesis.Apoptosis of target …
adenovirus EIB 19-kDa protein as well … dependent on RNA or protein synthesis.Apoptosis of target …
Synthesis of novel types of acyclic nucleoside phosphonates and preparation of prodrugs and drug delivery systems
F Kalčic - 2021 - dspace.cuni.cz
… while late stage is treated with melarsoprol or nifurtimox/… poxviruses, herpes viruses,
adenoviruses, and polyoma virus in … to protect and deprotect the 2-aminopurine group in CA and …
adenoviruses, and polyoma virus in … to protect and deprotect the 2-aminopurine group in CA and …
[PDF][PDF] A historical overview of protein kinase PKR: from its discovery and mechanism of action to its clinical and therapeutic implications
MÁG Chaves - An Real Acad Farm, 2016 - analesranf.com
… results in the inhibition of protein synthesis and the induction of … as vaccinia virus (VV),
adenovirus, or herpes simplex virus (… using the kinase inhibitor 2-aminopurine suggested a role for …
adenovirus, or herpes simplex virus (… using the kinase inhibitor 2-aminopurine suggested a role for …