… from parasites that were stably transfected with an apicoplast-… involved in apicoplast fatty
acid biosynthesis. Lipoylation is … , and recent data show that the mitochondrion can survive loss …

… families and channels for parasite survival. Consequently, … which is essential for de novo fatty
acid synthesis in the apicoplast (… mentioned as an essential co-factor in previous lists, but T. …

… gondii can survive temporarily without an apicoplast, such … some enzymes involved in fatty
acid biosynthesis. Initially, two … be localized to the apicoplast of malaria parasites. Use of a …

… pathogen, the parasite Toxoplasma gondii has lost its … in the apicoplast and producing lipoic,
myristic and palmitic acids; … of adaptation for the parasite to survive inside mammalian cells …

… Toxoplasma … in apicoplast-generated fatty acids. However, we show that increased
scavenging from the host or supplementation with exogenous fatty acids do not fully restore parasite …

… as well as de novo synthesis of fatty acids. In Toxoplasma gondii, fatty acid synthesis via
the apicoplast-localized FASII is essential for pathogenesis, while the role of two other fatty …

… with the synthesis of glycerol 3-phosphate and fatty acids from … biogenesis and parasite
survival in Toxoplasma gondii. … of CDP-DAG synthesis located in the ER and apicoplast of T. …

… the parasite apicoplast. The molecular and metabolic mechanisms allowing regulation and
channeling of these fatty acid fluxes for intracellular parasite survival … that Toxoplasma gondii …

… de novo fatty acid synthesis capacities in the apicoplast and (2) … The apicoplast is essential
for parasite survival in both T. … membrane biogenesis during cytokinesis and, most important, …

… that the Toxoplasma apicoplast membranelocalized phosphate translocator (TgAPT) is an
essential … precursor molecule for apicoplast fatty acid synthesis (FASII), PEP (Mazumdar and …