… Here, we show the involvement of epigenetic DNA methylation (DNAme) in metabolic … , and
with subsequent development of complications over an 18-yr period in the blood DNA of 499 …

… - and hyper-DNA methylation on cancer. In this review, we report new developments and
their implications regarding the effects of DNA methylation on cancer development. Indeed, …

… genes during development by differential DNA methylation. … of DNA methylation are necessary
for proper development and … The importance of DNA methylation to T-cell development is …

… methylation analysis was used to confirm and determine the fine structure of tissue specific
differences in DNA methylation. … changes in methylation at these loci during development. …

… of DNA methylation in silencing the transcription of key tumor suppressor genes and thus
promoting the development … changes working in concert with DNA methylation affect either the …

… DNA methylation occurs at cytosines, predominantly in the … reprogrammed during early
embryonic development as well as in … DNA methylation plays multiple roles during development …

… The heritability of methylation states and the secondary nature of the … methylation support
the idea that DNA methylation is adapted for a specific cellular memory function in development…

… A quarter century ago, one of the pioneers in the field of DNA methylation, Rudolf Jaenisch,
… about DNA methylation and speculated in which developmental contexts it might function [ …

… , are usually devoid of methylation [2]. DNA methylation is essential for mammalian development
and is involved in … Aberrant DNA methylation patterns and mutations of genes encoding …

… of the shape of genomic methylation patterns and the nature … development. We observe
that the sequences that undergo deep changes in methylation status during early development …