… Although PDE4 inhibition by roflumilast, a marketed drug that … , is effective in suppressing
airway hyper-responsiveness and … efficacy in the treatment of respiratory diseases, its role in IH-…

… that PDE 3 and 4 are found in airway smooth muscle, whilst PDE 3… Recently the selective
PDE4 inhibitor roflumilast-n-oxide has … of combination of dual PDE 3/4 inhibitors with other drug …

… and the archetypal member of the dual-specificity phosphatases (… 2 -agonists,
phosphodiesterase inhibitors and corticosteroids. … to airway disease that explain how MKP-1 is …

… effects of phosphodiesterase-4 inhibitors (PDE4Is). The repositioning and development
of efficacious PDE4Is for PD have gained much attention. This review critically assesses the …

… potential in the treatment of inflammatory diseases. … ), while sildenafil inhibited infiltration of
cells into the lungs (P < 0.05 … smooth muscle (41) through reduction of intracellular [Ca2+] and …

… effects of Cd were previously well proved. Cd induces inflammatory responses, oxidative
injury, mitochondrial dysfunction and disturbs Ca 2… the beneficial effects of NF-κB inhibitors that …

… The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role … inhibitors have been
investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases…

… allergic airway inflammation and asthma, phosphodiesterase … The data in this paper indicate
that the release of Ca 2+ via … PDE4 inhibitors like roflumilast have shown to be beneficial in …

… This suggests a beneficial effect of NO in allergic airway … The PDE4 inhibitor roflumilast
inhibits TGFβ-induced … : a novel series of potent dual PDE3/PDE4 inhibitory agents. Journal of …

… of chronic obstructive pulmonary disease (COPD) and … , the phosphodiesterase 4 (PDE 4)
inhibitor roflumilast-N-… its antispasmodic property is mediated via dual inhibition of PLCβ and …