Peripheral Opioid Analgesia: Neuroimmune Interactions and Therapeutic Implications

H Machelska, C Stein - Pain, 2003 - taylorfrancis.com
… have shown that peripheral antinociception mediated by µ-, δ-, and κ-opioid receptors is …
Interactions of immunederived opioid peptides and opioid receptors located in peripheral

Leukocyte-derived opioid peptides and inhibition of pain

H Machelska, C Stein - Journal of Neuroimmune Pharmacology, 2006 - Springer
Immune-derived opioid peptides apparently play a substantial role in the modulation of
inflammatory pain. POMC processing occurs in the endoplasmic reticulum and the trans-Golgi …

Peripheral analgesic and anti-inflammatory effects of opioids—neuro-immune crosstalk

H Machelska, C Stein - Mind over Matter-Regulation of Peripheral …, 2003 - Springer
… at peripheral opioid receptors are produced within immune cells and such immune-derived
This heralds an entirely new field, the selective targeting of opioid peptide-containing cells …

Pain control and the immune system

H Machelska, C Stein - Current Opinion in Anesthesiology, 1999 - journals.lww.com
… concerning the peripheral antinociceptive actions of locally applied exogenous opioid receptor
Immune-derived opioid peptides apparently play a substantial role in the modulation of …

Pain control by immune-derived opioids.

H Machelska, C Stein - Clinical & Experimental …, 2000 - search.ebscohost.com
… In vivo experiments have shown that the peripheral antinociceptive effects of p-, õ- and k-opioid
receptor-selective agonists are abolished by pretreatment with capsaicin, a neurotoxin …

Peripheral opioid analgesia

W Janson, C Stein - Advances in Palliative Medicine, 2004 - journals.viamedica.pl
antinociceptive effects of their ligands in inflammatory pain [30]. … opioid peptides using the
intraarticularly injected opioid antagonist naloxone [36]. Immune-derived endogenous opioids

Peripheral mechanisms of pain and analgesia

C Stein, JD Clark, U Oh, MR Vasko, GL Wilcox… - Brain research …, 2009 - Elsevier
… eg opioids, anticonvulsants) may be avoided. This article begins with the peripheral actions
of opioids… began to accumulate that the antinociceptive effects of opioids can be mediated by …

Targeting of opioid-producing leukocytes for pain control

H Machelska - Neuropeptides, 2007 - Elsevier
… selectively attract opioid-producing cells and increase peripheral opioid receptor numbers in
… question is whether immune-derived opioid peptides and exogenous opioids interact in an …

A review of the effects of pain and analgesia on immune system function and inflammation: relevance for preclinical studies

GJ DeMarco, EA Nunamaker - Comparative medicine, 2019 - ingentaconnect.com
… to CB1r results in antinociception by activation of descending antinociceptive pathways and
… effects of opioids on immune function, however, the exact mechanism by which opioids mod…

[PDF][PDF] Peripherally acting opioids and clinical implications for pain control

N Sehgal, HS Smith, L Manchikanti - Pain physician, 2011 - painphysicianjournal.com
… receptors is of significance in the manifestation of peripheral opioid anti-nociception; in … of
immune-derived opioid peptides into injured tissue and stimulate the endogenous peripheral