IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets

N Unver, F McAllister - Cytokine & growth factor reviews, 2018 - Elsevier
… Screening of cytokines can serve to identify immunological … as diagnostic biomarker and
this cytokine has also been … as well as potential therapeutic targets for treatment of cervical …

Potential therapeutic targets beyond cytokines and Janus kinases for autoimmune arthritis

CY Wu, HY Yang, JH Lai - Biochemical Pharmacology, 2023 - Elsevier
… serve as therapeutic targets [11]. To identify therapeutic targets beyond cytokines and JAKs
… We also propose and summarize potential novel therapeutic targets beyond those of current …

[HTML][HTML] Cytokine-defined B cell responses as therapeutic targets in multiple sclerosis

R Li, A Rezk, LM Healy, G Muirhead, A Prat… - Frontiers in …, 2016 - frontiersin.org
… of human cytokine-defined B … cytokine-defined B cells contribute to the peripheral immune
cascades that are thought to underlie MS relapses, and the impact of B cell-directed therapies

Current and emerging therapeutic targets for IBD

MF Neurath - Nature Reviews Gastroenterology & Hepatology, 2017 - nature.com
… blockers (such as ustekinumab and JAK inhibitors) suppressing cytokine signalling are
probably a new addition to our future clinical armamentarium for patients with IBD …

[HTML][HTML] Cytokine-modulating strategies and newer cytokine targets for arthritis therapy

SH Venkatesha, S Dudics, B Acharya… - International journal of …, 2014 - mdpi.com
… , are the prime therapeutic targets for this debilitating … cytokines are already in the clinic and
additional new ones are in clinical/preclinical trials. Gene therapy targeting these cytokines is …

[HTML][HTML] Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets

L Fania, G Moretta, F Antonelli, E Scala… - International Journal of …, 2022 - mdpi.com
cytokines in the pathogenesis of AD, considering patients with various clinical AD phenotypes.
Moreover, we describe the cytokine … the presence of multiple cytokine axes involved in the …

Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations

O Le Rouzic, M Pichavant, E Frealle… - European …, 2017 - Eur Respiratory Soc
… crucial to guide future therapeutics. As T-helper cell (Th)17 cytokines play a key role in driving
mucosal immune responses, this review focuses on the role of Th17 cytokines, interleukin (…

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer

LAJ O'Neill, CE Bryant, SL Doyle - Pharmacological reviews, 2009 - ASPET
… in this review, to justify them as therapeutic targets. These validation criteria are standard— …
inflammatory cytokines such as TNF and IL-6, which have proven to be excellent targets for …

Cytokines as therapeutic targets in primary Sjögren syndrome

S Retamozo, A Flores-Chavez… - … & therapeutics, 2018 - Elsevier
… potential pharmacotherapeutic options targeting the main cytokine families involved in the
etiopathogenesis of primary SjS and analyzes potential insights for developing new therapies. …

Investigating the Potential Mechanisms and Therapeutic Targets of Inflammatory Cytokines in Post-stroke Depression

Y Zhang, Y Yang, H Li, Q Feng, W Ge, X Xu - Molecular Neurobiology, 2024 - Springer
… of cytokines in stroke and PSD while identifying their potential as specific therapeutic targets
… regulating inflammatory cytokine expression and anti-inflammatory cytokines like interleukin-…