It is now well established that exogenous GH promotes sexual maturation and reproductive
function. The possibility that this may reflect physiological actions of endogenous GH has …

Testosterone (T) is known to affect the growth hormone (GH) axis. However, the
mechanisms underlying the activation of GH secretion by T still remain to be clarified …

A comprehensive study was undertaken to clarify the nature of a sex-based variation of
human growth hormone (HGH) secretion in man. This included a detailed investigation of …

We investigated the mechanisms by which androgens increase mean circulating GH
concentrations in boys. We tested two hypotheses: 1) testosterone increases serum GH …

Gender and age have distinct and interrelated effects on GH secretion in adults. GH
secretion falls significantly with aging, particularly in women. The fall in GH release is …

Glucocorticoids (GCs) modulate the somatotropic axis at a genomic and a non-genomic
level. Critical concentrations of steroids not only determine somatotrope differentiation but …

Testosterone (T) administration to pubertal boys increases spontaneous GH secretion. It is
not known whether this occurs via pituitary or hypothalamic mechanisms. We evaluated the …

The site-specific regulation of somatic growth by sex steroids is poorly understood. The aim
of the present study was to assess the influence of 17 beta-estradiol (E2) and 5 alpha …

Several trials with growth hormone (GH) replacement therapy in adults with GH deficiency
have been conducted during the last 10 years. Beneficial effects of treatment on bone …

We have determined whether oral estrogen reduces the biological effects of growth
hormone (GH) in GH-deficient (GHD) women compared with transdermal estrogen …