Oral Chlamydia vaccination induces transmucosal protection in the airway

C Zhu, H Lin, L Tang, J Chen, Y Wu, G Zhong - Vaccine, 2018 - Elsevier
Although Chlamydia has been frequently detected in the gastrointestinal tracts of both
humans and animals, it is not associated with any gastrointestinal pathology. We have …

Intranasal immunization induces long-term protection in mice against a Chlamydia trachomatis genital challenge

S Pal, EM Peterson, LM De La Maza - Infection and immunity, 1996 - Am Soc Microbiol
In an attempt to confer long-term protective immunity, BALB/c female mice were immunized
intranasally with 10 (4) inclusion-forming units (IFU) of the Chlamydia trachomatis mouse …

Approach to discover T- and B-cell antigens of intracellular pathogens applied to the design of Chlamydia trachomatis vaccines

O Finco, E Frigimelica, F Buricchi… - Proceedings of the …, 2011 - National Acad Sciences
Natural immunity against obligate and/or facultative intracellular pathogens is usually
mediated by both humoral and cellular immunity. The identification of those antigens …

CD4+ T Cells and Antibody Are Required for Optimal Major Outer Membrane Protein Vaccine-Induced Immunity to Chlamydia muridarum Genital Infection

CM Farris, SG Morrison, RP Morrison - Infection and immunity, 2010 - Am Soc Microbiol
Despite effective antimicrobial chemotherapy, control of Chlamydia trachomatis urogenital
infection will likely require a vaccine. We have assessed the protective effect of an outer …

Intranasal immunization with Chlamydia trachomatis, serovar E, protects from a subsequent vaginal challenge with the homologous serovar

EM Peterson, JZ You, V Motin, LM de la Maza - Vaccine, 1999 - Elsevier
To vaccinate against a vaginal challenge with Chlamydia trachomatis, C3H/HeJ (H-2k) mice
were immunized intranasally (in) or intraperitoneally (ip) with 1× 106 inclusion forming units …

Immunopathogenesis of genital Chlamydia infection: insights from mouse models

J Dockterman, J Coers - Pathogens and Disease, 2021 - academic.oup.com
Chlamydiae are pathogenic intracellular bacteria that cause a wide variety of diseases
throughout the globe, affecting the eye, lung, coronary arteries and female genital tract …

Identification and characterization of novel recombinant vaccine antigens for immunization against genital Chlamydia trachomatis

RN Coler, A Bhatia, JF Maisonneuve… - FEMS Immunology & …, 2009 - academic.oup.com
Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection
worldwide, with over 91 million cases estimated annually. An effective subunit vaccine …

The Infecting Dose of Chlamydia muridarum Modulates the Innate Immune Response and Ascending Infection

HK Maxion, W Liu, MH Chang, KA Kelly - Infection and immunity, 2004 - Am Soc Microbiol
Murine vaginal infection with the obligate intracellular bacterium Chlamydia muridarum is
commonly used as a model for ascending Chlamydia infections of the human female genital …

Induction of antibody response to Chlamydia trachomatis in the genital tract by oral immunization

ZD Cui, D Tristram, LJ LaScolea… - Infection and …, 1991 - Am Soc Microbiol
Groups of BALB/c mice were orally immunized with Chlamydia trachomatis serovar
L2/434/Bu in order to characterize the nature and kinetics of the chlamydial antibody …

Immunization with a combination of integral chlamydial antigens and a defined secreted protein induces robust immunity against genital chlamydial challenge

W Li, AK Murthy, MN Guentzel, JP Chambers… - Infection and …, 2010 - Am Soc Microbiol
We have previously demonstrated the efficacy of recombinant chlamydial protease-like
activity factor (rCPAF; a secreted chlamydial protein) in inducing antigen-specific CD4+ T …