[HTML][HTML] The carbon and energy sources of the non-photosynthetic plastid in the malaria parasite

L Lim, M Linka, KA Mullin, APM Weber, GI McFadden - FEBS letters, 2010 - Elsevier
The malaria parasite harbours an indispensable plastid known as the 'apicoplast'. The
apicoplast's exact role remains uncertain, but it houses components involved in fatty acid …

Apicoplast fatty acid biosynthesis as a target for medical intervention in apicomplexan parasites

P Gornicki - International journal for parasitology, 2003 - Elsevier
New chemotherapies for human and animal apicomplexan infections are needed as a
component of future strategies to deal with these diseases. An extensive search for new …

[HTML][HTML] Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

E Yeh, JL DeRisi - PLoS biology, 2011 - journals.plos.org
Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to
its prokaryotic origin and essential function, the apicoplast is a key target for development of …

[HTML][HTML] The flexibility of Apicomplexa parasites in lipid metabolism

S Shunmugam, CS Arnold, S Dass, NJ Katris… - PLoS …, 2022 - journals.plos.org
Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

[HTML][HTML] Phosphatidylinositol 3-Monophosphate Is Involved in Toxoplasma Apicoplast Biogenesis

L Tawk, JF Dubremetz, P Montcourrier… - PLoS …, 2011 - journals.plos.org
Apicomplexan parasites cause devastating diseases including malaria and toxoplasmosis.
They harbour a plastid-like, non-photosynthetic organelle of algal origin, the apicoplast …

[HTML][HTML] A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites

Y Tang, TR Meister, M Walczak, MJ Pulkoski-Gross… - PLoS …, 2019 - journals.plos.org
Endosymbiosis has driven major molecular and cellular innovations. Plasmodium spp.
parasites that cause malaria contain an essential, non-photosynthetic plastid—the …

The apicoplast: now you see it, now you don't

GI McFadden, E Yeh - International journal for parasitology, 2017 - Elsevier
Parasites such as Plasmodium and Toxoplasma possess a vestigial plastid homologous to
the chloroplasts of algae and plants. The plastid (known as the apicoplast; for apicomplexan …

The apicoplast: a review of the derived plastid of apicomplexan parasites

RF Waller, GI McFadden - Current issues in molecular biology, 2005 - mdpi.com
The apicoplast is a plastid organelle, homologous to chloroplasts of plants, that is found in
apicomplexan parasites such as the causative agents of Malaria Plasmodium spp. It occurs …

Make it or take it: fatty acid metabolism of apicomplexan parasites

J Mazumdar, B Striepen - Eukaryotic cell, 2007 - Am Soc Microbiol
Lipids are essential and highly abundant components of all organisms. They serve as the
main building blocks of the membranes that surround and compartmentalize cells, as a store …

Validation of putative apicoplast-targeting drugs using a chemical supplementation assay in cultured human malaria parasites

T Uddin, GI McFadden… - Antimicrobial agents and …, 2018 - Am Soc Microbiol
Malaria parasites contain a relict plastid, the apicoplast, which is considered an excellent
drug target due to its bacterial-like ancestry. Numerous parasiticidals have been proposed to …