Purpose: Recombinant BMP-7 inhibits the pathogenesis of renal injury in response to
various stimuli. However, little is known about the molecular regulation of endogenous BMP …

It has been shown that blockade of Rho kinase with pharmacologic inhibitors inhibits renal
fibrosis. This study examined the role of Rho kinase in renal fibrosis in the unilateral ureteral …

Aims Tubulointerstitial fibrosis, a frequent complication of chronic kidney disease (CKD) is a
major public health issue. Biochanin A (BCA), an isoflavone, has numerous …

Transforming growth factor β (TGF-β)/Smad3 signaling plays a role in tissue fibrosis. We
report here that Erbb4-IR is a novel long non-coding RNA (lncRNA) responsible for TGF …

Transforming growth factor-β (TGF-β) is a potent pathogenic factor of renal injury through the
upregulation of extracellular matrix (ECM) expression and facilitation of renal fibrosis …

Renal fibrosis is the final common pathway of chronic kidney disease (CKD), and no
effective medication is available clinically for managing its progression. Metformin was …

Renal inflammation has a key role in the onset and progression of immune–and nonimmune–
mediated renal diseases. Therefore, the search for novel anti–inflammatory pharmacologic …

TGF-β is a key profibrotic factor, but targeting TGF-β to prevent fibrosis also abolishes its
protective anti-inflammatory effects. Here, we investigated the hypothesis that we can …

The Wnt/β-catenin signaling pathway plays important roles in embryonic development and
tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the …

Aim To investigate the potential effects of berberine on renal interstitial fibrosis (RIF) of
obstructed kidneys in a unilateral ureteral obstruction (UUO) rat model. Methods Forty‐eight …