Background Microglia activation is a crucial event in neurodegenerative disease. The
depression of microglial inflammatory response is considered a promising therapeutic …

Epigenetic mechanisms are implicated in transcriptional programs driving chronic kidney
disease (CKD). Apabetalone is an orally available inhibitor of bromodomain and …

Abstract Protease-activated receptor (PAR)-1 has emerged as a key profibrotic player in
various organs including kidney. PAR-1 activation leads to deposition of extracellular matrix …

Radiation-induced lung injury has restricted radiotherapy for thoracic cancer. The purpose of
this study was to investigate the radioprotective effects of bromodomain and extra terminal …

Progressive glomerulonephritis (GN) is characterized by an excessive accumulation of
extracellular (ECM) proteins, mainly type IV collagen (COLIV), in the glomerulus leading to …

Tubulointerstitial fibrosis has been regarded as a critical event in the pathogenesis of
chronic kidney disease. The soluble form of (pro) renin receptor (sPRR), generated by site-1 …

Background and Objective. Progressive pulmonary fibrosis is the main cause of death in
patients with systemic sclerosis (SSc) with interstitial lung disease (ILD) and in those with …

Aim Fibrosis is the most common complication from chronic diseases, and yet no therapy
capable of mitigating its effects is available. Our goal is to unveil specific signaling regulating …

Histones are the most abundant proteins bound to DNA in eukaryotic cells and frequently
subjected to post-modifications such as acetylation, methylation, phosphorylation and …

Renal interstitial fibrosis (RIF) is a common manifestation of inflammatory and
noninflammatory renal diseases, which correlates to renal excretory dysfunction. Recently …