The extracellular matrix in glioblastomas: a glance at its structural modifications in shaping the tumoral microenvironment—a Systematic review
S Marino, G Menna, R Di Bonaventura, L Lisi… - Cancers, 2023 - mdpi.com
Simple Summary The new trends in the research on glioblastomas (GBMs) are focusing on
understanding the crosstalk between proper neoplastic tissue and its microenvironment …
understanding the crosstalk between proper neoplastic tissue and its microenvironment …
[HTML][HTML] P4HA2 promotes epithelial-to-mesenchymal transition and glioma malignancy through the collagen-dependent PI3K/AKT pathway
J Lin, L Jiang, X Wang, W Wei, C Song, Y Cui… - Journal of …, 2021 - hindawi.com
Prolyl-4-hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes
involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …
involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …
Decellularization of tumours: A new frontier in tissue engineering
E García-Gareta, MÁ Pérez… - Journal of Tissue …, 2022 - journals.sagepub.com
Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix
(ECM) has unique features in terms of composition and mechanical properties, resulting in a …
(ECM) has unique features in terms of composition and mechanical properties, resulting in a …
Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma
Originating in the brain, glioblastoma (GBM) is a highly lethal and virtually incurable cancer,
in large part because it readily develops resistance to treatments. While numerous studies …
in large part because it readily develops resistance to treatments. While numerous studies …
Cancer and apoptosis
Cancer is an uncontrolled growth of normal cells due to unchecked regulatory mechanisms
working inside the rapidly dividing cells. In this complex cancer disease treatment, various …
working inside the rapidly dividing cells. In this complex cancer disease treatment, various …
Structure–redox–relaxivity relationships for redox responsive manganese-based magnetic resonance imaging probes
EM Gale, S Mukherjee, C Liu, GS Loving… - Inorganic …, 2014 - ACS Publications
A library of 10 Mn-containing complexes capable of switching reversibly between the Mn (II)
and Mn (III) oxidation states was prepared and evaluated for potential usage as MRI …
and Mn (III) oxidation states was prepared and evaluated for potential usage as MRI …
Collagen fibers provide guidance cues for capillary regrowth during regenerative angiogenesis in zebrafish
A Senk, V Djonov - Scientific reports, 2021 - nature.com
Although well investigated, the importance of collagen fibers in supporting angiogenesis is
not well understood. In this study, we demonstrate that extracellular collagen fibers provide …
not well understood. In this study, we demonstrate that extracellular collagen fibers provide …
Engineered hydrogels for brain tumor culture and therapy
Brain tumors' severity ranges from benign to highly aggressive and invasive. Bioengineering
tools can assist in understanding the pathophysiology of these tumors from outside the body …
tools can assist in understanding the pathophysiology of these tumors from outside the body …
[HTML][HTML] Decellularized brain extracellular matrix slice glioblastoma culture model recapitulates the interaction between cells and the extracellular matrix without a …
C Wang, Q Zhao, X Zheng, S Li, J Chen, H Zhao… - Acta Biomaterialia, 2023 - Elsevier
Decellularized extracellular matrix (dECM) is a valuable tool for generating three-
dimensional in vitro tumor models that effectively recapitulate tumor-extracellular matrix …
dimensional in vitro tumor models that effectively recapitulate tumor-extracellular matrix …
Mitochondrial glutamate transporter SLC25A22 uni-directionally export glutamate for metabolic rewiring in radioresistant glioblastoma
Glioblastoma Multiforme (GBM) is a malignant primary brain tumor. Radiotherapy, one of the
standard treatments for GBM patients, could induce GBM radioresistance via rewiring …
standard treatments for GBM patients, could induce GBM radioresistance via rewiring …