The extracellular matrix in glioblastomas: a glance at its structural modifications in shaping the tumoral microenvironment—a Systematic review

S Marino, G Menna, R Di Bonaventura, L Lisi… - Cancers, 2023 - mdpi.com
Simple Summary The new trends in the research on glioblastomas (GBMs) are focusing on
understanding the crosstalk between proper neoplastic tissue and its microenvironment …

[HTML][HTML] P4HA2 promotes epithelial-to-mesenchymal transition and glioma malignancy through the collagen-dependent PI3K/AKT pathway

J Lin, L Jiang, X Wang, W Wei, C Song, Y Cui… - Journal of …, 2021 - hindawi.com
Prolyl-4-hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes
involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …

Decellularization of tumours: A new frontier in tissue engineering

E García-Gareta, MÁ Pérez… - Journal of Tissue …, 2022 - journals.sagepub.com
Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix
(ECM) has unique features in terms of composition and mechanical properties, resulting in a …

Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma

W Xiao, S Wang, R Zhang, A Sohrabi, Q Yu, S Liu… - Matrix Biology, 2020 - Elsevier
Originating in the brain, glioblastoma (GBM) is a highly lethal and virtually incurable cancer,
in large part because it readily develops resistance to treatments. While numerous studies …

Cancer and apoptosis

GS Chaudhry, AM Akim, YY Sung… - Apoptosis and cancer …, 2022 - Springer
Cancer is an uncontrolled growth of normal cells due to unchecked regulatory mechanisms
working inside the rapidly dividing cells. In this complex cancer disease treatment, various …

Structure–redox–relaxivity relationships for redox responsive manganese-based magnetic resonance imaging probes

EM Gale, S Mukherjee, C Liu, GS Loving… - Inorganic …, 2014 - ACS Publications
A library of 10 Mn-containing complexes capable of switching reversibly between the Mn (II)
and Mn (III) oxidation states was prepared and evaluated for potential usage as MRI …

Collagen fibers provide guidance cues for capillary regrowth during regenerative angiogenesis in zebrafish

A Senk, V Djonov - Scientific reports, 2021 - nature.com
Although well investigated, the importance of collagen fibers in supporting angiogenesis is
not well understood. In this study, we demonstrate that extracellular collagen fibers provide …

Engineered hydrogels for brain tumor culture and therapy

J Thakor, S Ahadian, A Niakan, E Banton… - Bio-design and …, 2020 - Springer
Brain tumors' severity ranges from benign to highly aggressive and invasive. Bioengineering
tools can assist in understanding the pathophysiology of these tumors from outside the body …

[HTML][HTML] Decellularized brain extracellular matrix slice glioblastoma culture model recapitulates the interaction between cells and the extracellular matrix without a …

C Wang, Q Zhao, X Zheng, S Li, J Chen, H Zhao… - Acta Biomaterialia, 2023 - Elsevier
Decellularized extracellular matrix (dECM) is a valuable tool for generating three-
dimensional in vitro tumor models that effectively recapitulate tumor-extracellular matrix …

Mitochondrial glutamate transporter SLC25A22 uni-directionally export glutamate for metabolic rewiring in radioresistant glioblastoma

E Shin, B Kim, H Kang, H Lee, J Park, JH Kang… - International Journal of …, 2023 - Elsevier
Glioblastoma Multiforme (GBM) is a malignant primary brain tumor. Radiotherapy, one of the
standard treatments for GBM patients, could induce GBM radioresistance via rewiring …