Ischemic stroke refers to brain tissue ischemia, hypoxic necrosis, and brain softening caused
by the interruption of the blood supply to the brain without adequate collateral circulation …

The presence of ubiquitinated protein inclusions is a hallmark of most adult onset
neurodegenerative disorders. Although the toxicity of these structures remains controversial …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by selective loss
of motor neurons (MNs). About 20% familial cases of ALS (fALS) carried the Cu, Zn …

Autophagy is a tightly regulated cell self-eating process. It has been shown to be associated
with various neuropathological conditions and therefore, traditionally known as a stress …

The multiplicity of cell death mechanisms induced by neonatal hypoxia-ischemia makes
neuroprotective treatment against neonatal asphyxia more difficult to achieve. Whereas the …

LC3 belongs to a novel ubiquitin-like protein family that is involved in different intracellular
trafficking processes, including autophagy. All members of this family share a unique three …

Mechanisms of neuronal loss in Alzheimer's disease (AD) are poorly understood. Here we
show that apoptosis is a major form of neuronal cell death in PS/APP mice modeling AD-like …

The mechanism of widespread neuronal death occurring in Alzheimer's disease (AD)
remains enigmatic even after extensive investigation during the last two decades. Amyloid …

Macroautophagy is an essential degradative pathway that can be induced to clear
aggregated proteins, such as those found in Parkinson's disease and dementia with Lewy …

Autophagy is a major intracellular catabolic pathway that takes part in diverse biological
events including response to amino acid starvation, protein and organelle turnover …