Background Hepatic encephalopathy (HE) is a reversible neuropsychiatric syndrome
associated with acute and chronic liver diseases. It includes a number of neuropsychiatric …

Lysosomal ion channels mediate ion flux from lysosomes and regulate membrane potential
across the lysosomal membrane, which are essential for lysosome biogenesis, nutrient …

Mitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain
mitochondria are the primary source of fuel that supports many brain functions, including …

CNS cell membranes possess four transporters capable of exchanging Lglutamine (Gln) for
other amino acids: the large neutral amino acid (LNAA) transporters LAT1 and LAT2, the …

Background: Resveratrol is a polyphenolic compound that presents several protective
effects in the central nervous system, including gliotoxicity associated to hyperammonemia …

Chemogenetics refers to experimental systems that dynamically regulate the activity of a
recombinant protein by providing or withholding the protein's specific biochemical stimulus …

Although endothelial cells produce substantial quantities of ammonia during cell
metabolism, the physiologic role of this gas in these cells is not known. In this study, we …

Ammonia could be regarded as one detrimental pollutant with an acrid smell in livestock
sheds. So far, the pig breeding industry became the main source of atmospheric ammonia …

Ammonia is considered to be the main neurotoxin responsible for hepatic encephalopathy
resulting from liver failure. Liver failure has been reported to alter expression and activity of …

Hepatic encephalopathy (HE) is a cerebral function alteration in patients with liver
dysfunction. The present study aimed to evaluate the therapeutic effects of thymoquinone …