Re-evaluation of fibrogenic cytokines in lung fibrosis

M Kelly, M Kolb, P Bonniaud… - Current pharmaceutical …, 2003 - ingentaconnect.com
… that treatment of patients with IPF with a combination of IFN-γ-1b and prednisolone resulted
… in normal passage through the tissue modulating susceptibility to normal apoptosis, resulting …

Pharmacological therapy for idiopathic pulmonary fibrosis: past, present, and future

RJ MASON, MI SCHWARZ… - … and Critical Care …, 1999 - atsjournals.org
… of corticosteroids apply to … IFN-γ inhibits a fibrogenic growth factor produced by mast cells,
fibroblast growth factor-2 (FGF-2, basic FGF) (37), and a variety of neutrophil-derived cytokines

Growth factors in idiopathic pulmonary fibrosis: relative roles

JT Allen, MA Spiteri - Respiratory research, 2001 - Springer
… , in which the roles of "various cytokines and growth factors" are … A preliminary trial of IFN-γ
co-therapy in IPF patients led to … modulation in pulmonary alveolar myo-fibroblasts during …

Efficacy and safety of pirfenidone for idiopathic pulmonary fibrosis

Y Takeda, K Tsujino, T Kijima… - Patient preference and …, 2014 - Taylor & Francis
… shown to be a modulator of cytokines and growth factors, … of IFN-γ, which is known to be an
anti-fibrotic cytokine through … -steroid agents for the treatment of IPF and identified IFN-γ-1b

Emerging therapeutic interventions for idiopathic pulmonary fibrosis

S Chakraborty, P Chopra, SV Ambi… - Expert opinion on …, 2014 - Taylor & Francis
… Administration of IFN-γ, an immunomodulatory cytokine, has … This trial enrolled 826 patients
with IPF to receive either IFN-γ … by modulating the expression of pro-fibrotic cytokines such as …

Role of galectin-3 in human pulmonary fibrosis

Y Nishi, H Sano, T Kawashima, T Okada, T Kuroda… - Allergology …, 2007 - Elsevier
… Interestingly, an anti-fibrotic cytokine IFN-γ also stimulated … Therefore, we propose that a
combination of IFN-γ therapy with … Immunocytochemical evidence for a modulation of galectin 3 …

Thalidomide reduces IL-18, IL-8 and TNF-α release from alveolar macrophages in interstitial lung disease

Q Ye, B Chen, Z Tong, S Nakamura… - European …, 2006 - Eur Respiratory Soc
… No patient was receiving corticosteroid and/or … patients in the current study, suggesting
different modulating effects … cytokine IFN-γ upon stimulation, while their ability to release the Th2 …

Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses

P Wang, J Leung, A Lam, S Lee, DR Calabrese… - The Journal of Heart and …, 2022 - Elsevier
… from the use of immunosuppression as a treatment for IPF. Post-… cytokine production with
IPF subjects in group 3 displaying a preserved proliferative type 1 cytokine response (IL-2, IFN-γ

Evidence-based treatment strategies in idiopathic pulmonary fibrosis

J Behr - European Respiratory Review, 2013 - Eur Respiratory Soc
… effect of IFN-γ-1b compared with placebo treatment in IPF patients in … are associated with
modulation of cytokines and growth … of corticosteroids and an immunosuppressive agent (eg. …

Clinical use of interferon‐γ

CHT Miller, SG Maher, HA Young - … of the New York Academy of …, 2009 - Wiley Online Library
… Interferon gamma (IFN-γ), a cytokine with diverse roles in the … 31 of IPF patients, IFN-γ treatment
in combination with prednisolone … on viral infection but did modulate the immune system. …