Inhibition of Src family kinases ameliorates LPS-induced acute kidney injury and mitochondrial dysfunction in mice
ES Pak, MJ Uddin, H Ha - International Journal of Molecular Sciences, 2020 - mdpi.com
… These alterations were prevented by PP2, a pan SFK inhibitor. … have been shown to be
related to diabetic kidney disease [13… Non-specific binding was blocked with serum-free blocking …
related to diabetic kidney disease [13… Non-specific binding was blocked with serum-free blocking …
Podocarpusflavone alleviated renal fibrosis in obstructive nephropathy by inhibiting Fyn/Stat3 signaling pathway
B Zhu, R Han, Y Ni, H Guo, X Liu, J Li… - Journal of Natural …, 2023 - Springer
… that treatment with POD inhibited the aggravated activation of Fyn … The extraction and
identification of mouse TECs refer to our … of diabetes nephropathy, it was found that Src kinase was …
identification of mouse TECs refer to our … of diabetes nephropathy, it was found that Src kinase was …
Insights into the Therapeutic Potential of Phytoconstituents as an Epigenetic Modulators in Diabetic Nephropathy
… ) and Ets-1 in mesangial cells located in the renal glomeruli of mice [80]. An upregulation
of … to inhibition of ECM accumulation, and HMC proliferation as well as high glucose–induced …
of … to inhibition of ECM accumulation, and HMC proliferation as well as high glucose–induced …
Upregulation of the protein kinase Lyn is associated with renal injury in type 2 diabetes patients
J Chen, L Peng, J Sun, J Liu, L Chu, B Yi, M Gui… - Renal …, 2023 - Taylor & Francis
… with diabetic kidney disease (DKD) and in kidney tissues of streptozotocin (STZ)-induced
DKD mice. … that administration of the Src family kinase inhibitor PP2 decreases proteinuria and …
DKD mice. … that administration of the Src family kinase inhibitor PP2 decreases proteinuria and …
The mechanistic role of different mediators in the pathophysiology of nephropathy: A review
… , inhibition of PDGF results in the reduction of mesangial cell … AGEs play a role in the
pathogenesis of diabetic nephropathy … kinase-1 pathway mediates high glucose-induced …
pathogenesis of diabetic nephropathy … kinase-1 pathway mediates high glucose-induced …
Targeting canonical and non-canonical STAT signaling pathways in renal diseases
L Gai, Y Zhu, C Zhang, X Meng - Cells, 2021 - mdpi.com
… Diabetic nephropathy (DN) is one of the most serious vascular complications of … or inhibition
of STAT1 could suppress IFN-γ-induced MHC class II expression in mesangial cells and …
of STAT1 could suppress IFN-γ-induced MHC class II expression in mesangial cells and …
Mineralocorticoid receptor-associated mechanisms in diabetic kidney disease and clinical significance of mineralocorticoid receptor antagonists
CW Mende, R Samarakoon, PJ Higgins - American Journal of …, 2023 - karger.com
… High glucose levels in diabetic nephropathy mobilize the Rho pathway in mesangial cells,
and … Furthermore, glucose-induced Rac1 stimulation contributed to renal MR activation in …
and … Furthermore, glucose-induced Rac1 stimulation contributed to renal MR activation in …
Angiotensin II as a mediator of renal fibrogenesis
I Loeffler, G Wolf - Angiotensin, 2023 - Elsevier
… of APA in mouse mesangial cells attenuated the proliferative … to aggravation of diabetic
nephropathy in mice in comparison … the glucose-induced PRR translocation to the apical cell side …
nephropathy in mice in comparison … the glucose-induced PRR translocation to the apical cell side …
Pathophysiological impact of the MEK5/ERK5 pathway in oxidative stress
I Tusa, A Menconi, A Tubita, E Rovida - Cells, 2023 - mdpi.com
… Otsuka Long Evans Tokushima Fatty rats, which display diabetic nephropathy at 52 weeks
of age. High glucose-induced ERK5 activation in cultured rat mesangial cells was reduced by …
of age. High glucose-induced ERK5 activation in cultured rat mesangial cells was reduced by …
[HTML][HTML] Exploring the mechanism of Dahuang-Tusizi drug pair in the treatment of diabetes nephropathy based on network pharmacology and immune infiltration …
W Liu, L Yuan, M Che, S Hou, F Meng, D Xu, Y Nan - Medicine, 2023 - journals.lww.com
… We predicted that DTDP may inhibit inflammation related … of kidney, which effectively prevents
the accumulation of … , primarily synthesized by tubular epithelial cells and mesangial cells. …
the accumulation of … , primarily synthesized by tubular epithelial cells and mesangial cells. …