Plugging the holes in hepatitis C virus antiviral therapy
SDC Griffin - Proceedings of the National Academy of …, 2009 - National Acad Sciences
… M2 proton channel of influenza A virus, which is the target for the antiviral drugs amantadine
… for viroporins as therapeutic targets that has driven research into the ion channels of other …
… for viroporins as therapeutic targets that has driven research into the ion channels of other …
How to overcome resistance of influenza A viruses against adamantane derivatives
C Scholtissek, G Quack, HD Klenk, RG Webster - Antiviral research, 1998 - Elsevier
… targets, with the M2 ion channel and the HA function at the same concentration, might have
a reduced probability to develop resistance. In this case, two mutations, one in each target …
a reduced probability to develop resistance. In this case, two mutations, one in each target …
[HTML][HTML] Host calcium channels and pumps in viral infections
X Chen, R Cao, W Zhong - Cells, 2019 - mdpi.com
… , receptor-operated channels, transient receptor potential ion channels, and … antiviral drugs.
In this present review, the recent identified cellular calcium channels and pumps as targets …
In this present review, the recent identified cellular calcium channels and pumps as targets …
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
… The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs amantadine
and rimantadine, whose use has been discontinued due to widespread drug resistance. …
and rimantadine, whose use has been discontinued due to widespread drug resistance. …
[HTML][HTML] The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels
DE Chandler, F Penin, K Schulten, C Chipot - 2012 - journals.plos.org
… oligomeric protein harboring ion channel activity. It is essential for effective assembly and
release of infectious HCV particles and an attractive target for antiviral intervention. Yet, the self…
release of infectious HCV particles and an attractive target for antiviral intervention. Yet, the self…
[HTML][HTML] NMR structure and ion channel activity of the p7 protein from hepatitis C virus
R Montserret, N Saint, C Vanbelle, AG Salvay… - Journal of Biological …, 2010 - ASBMB
… ion channel activity essential for virus infectivity. These viroporin features render p7 an
attractive target for antiviral … synthesized and purified for ion channel activity measurements and …
attractive target for antiviral … synthesized and purified for ion channel activity measurements and …
[HTML][HTML] Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking
SJ Dobson, J Mankouri, A Whitehouse - Antiviral Research, 2020 - Elsevier
… channels to specifically target host cell ion channel functionality, we show that MCPyV, but
not SV40 can be inhibited by K + channel … spectrum Ca 2+ channel inhibitor verapamil. Using …
not SV40 can be inhibited by K + channel … spectrum Ca 2+ channel inhibitor verapamil. Using …
[HTML][HTML] Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention
E De Clercq, J Neyts - Trends in pharmacological sciences, 2007 - cell.com
… M2 ion channel blockers Do any antiviral agents other than neuraminidase inhibitors
have potential in the control (prevention or therapy) of influenza A (H5N1) infections? The …
have potential in the control (prevention or therapy) of influenza A (H5N1) infections? The …
[HTML][HTML] Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates
Y Wang, S Fang, Y Wu, X Cheng, L Zhang… - Acta Pharmacologica …, 2022 - nature.com
… 2-E channel is an effective antiviral drug target and provides a potential antiviral candidate
… After ion channel conductance was detected, 100 μM compounds were added to the trans …
… After ion channel conductance was detected, 100 μM compounds were added to the trans …
A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to …
SDC Griffin, R Harvey, DS Clarke… - Journal of General …, 2004 - microbiologyresearch.org
… ion channel activity in cellular membranes and its inhibition by amantadine affirm the
protein as a target … an opportunity for a new direction of research for antiviral chemotherapy. …
protein as a target … an opportunity for a new direction of research for antiviral chemotherapy. …