Plugging the holes in hepatitis C virus antiviral therapy

SDC Griffin - Proceedings of the National Academy of …, 2009 - National Acad Sciences
… M2 proton channel of influenza A virus, which is the target for the antiviral drugs amantadine
… for viroporins as therapeutic targets that has driven research into the ion channels of other …

How to overcome resistance of influenza A viruses against adamantane derivatives

C Scholtissek, G Quack, HD Klenk, RG Webster - Antiviral research, 1998 - Elsevier
targets, with the M2 ion channel and the HA function at the same concentration, might have
a reduced probability to develop resistance. In this case, two mutations, one in each target

[HTML][HTML] Host calcium channels and pumps in viral infections

X Chen, R Cao, W Zhong - Cells, 2019 - mdpi.com
… , receptor-operated channels, transient receptor potential ion channels, and … antiviral drugs.
In this present review, the recent identified cellular calcium channels and pumps as targets

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

J Wang, Y Wu, C Ma, G Fiorin, J Wang… - Proceedings of the …, 2013 - National Acad Sciences
… The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs amantadine
and rimantadine, whose use has been discontinued due to widespread drug resistance. …

[HTML][HTML] The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels

DE Chandler, F Penin, K Schulten, C Chipot - 2012 - journals.plos.org
… oligomeric protein harboring ion channel activity. It is essential for effective assembly and
release of infectious HCV particles and an attractive target for antiviral intervention. Yet, the self…

[HTML][HTML] NMR structure and ion channel activity of the p7 protein from hepatitis C virus

R Montserret, N Saint, C Vanbelle, AG Salvay… - Journal of Biological …, 2010 - ASBMB
ion channel activity essential for virus infectivity. These viroporin features render p7 an
attractive target for antiviral … synthesized and purified for ion channel activity measurements and …

[HTML][HTML] Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking

SJ Dobson, J Mankouri, A Whitehouse - Antiviral Research, 2020 - Elsevier
channels to specifically target host cell ion channel functionality, we show that MCPyV, but
not SV40 can be inhibited by K + channel … spectrum Ca 2+ channel inhibitor verapamil. Using …

[HTML][HTML] Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention

E De Clercq, J Neyts - Trends in pharmacological sciences, 2007 - cell.com
… M2 ion channel blockers Do any antiviral agents other than neuraminidase inhibitors
have potential in the control (prevention or therapy) of influenza A (H5N1) infections? The …

[HTML][HTML] Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates

Y Wang, S Fang, Y Wu, X Cheng, L Zhang… - Acta Pharmacologica …, 2022 - nature.com
… 2-E channel is an effective antiviral drug target and provides a potential antiviral candidate
… After ion channel conductance was detected, 100 μM compounds were added to the trans …

A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to …

SDC Griffin, R Harvey, DS Clarke… - Journal of General …, 2004 - microbiologyresearch.org
ion channel activity in cellular membranes and its inhibition by amantadine affirm the
protein as a target … an opportunity for a new direction of research for antiviral chemotherapy. …