… It demonstrates novel strategies to suppress the therapy-tolerant state … advanced PCa.
Since enhanced GPX4 dependence is an adaptive phenotype shared by several types of cancer …

… in clinical investigation and drug development. It takes a … Tumor growth rates derived from
data for patients in a clinical trial correlate strongly with patient survival: a novel strategy for …

… AMPK's final biological output is then determined … drug development efforts. Here, we
propose a mechanistic explanation to assist in understanding how AMPK works in prostate cancer …

… have the potential to accelerate drug development 13, 14. … trials in advancing novel drugs
and drug combinations into the … of human CRPC and allows for hypothesis-driven cause-and-…

… novel targeted therapeutics are currently under research. … , the ‘establishment of preclinical
models that recapitulate biology … In this Review, we summarize the hypotheses of the origin of …

… prostate cancer biology and disease resistance mechanisms has grown over the past few
years, drug … These findings support the hypothesis that GR upregulation promotes resistance …

… described how the optimal evaluation of novel agents for the … by testing the obtained
AUCs against a null hypothesis of 0.5… of the molecular biology mechanisms driving disease …

… , our perspective on cancer cell biology has evolved from a … phenotype, meaning that novel
therapeutics are still required. … support the hypothesis that AR-mediated drug resistance …

… the most recognized pathogenetic hypotheses. However, recently novel theories such as the
… such as the generation of large-scale biological data sets, called –omics data, that have led …

… One area of drug development has focused on agents that … newest hypotheses surrounding
possible therapeutics for CR-PCa, these … Clinical trials testing novel agents continue, but the …