The sequence specificity of ten cisplatin analogues was examined in intact human cells. Six
of these compounds have anti-tumour activity. The sequence selectivity was investigated …

Extent of DNA platination, loss of cell viability, DNA fragmentation, and impairment of cellular
mitochondrial oxygen consumption are measures of drug cytotoxicity. We measured and …

Abstract interesting representatives of a new generation of platinum-based cytostatic drugs
that are currently being tested in clinical trials are lobaplatin [1, 2-diaminomethyl …

Every bulky lesion in DNA can potentially inhibit the Taq DNA polymerase and thereby
decrease the amplification produced in the polymerase chain reaction. We investigated the …

Platinum was lost from the DNA of cis-diamminedichloroplatinum (II)[cis-Pt (II)]-treated
exponentially growing Chinese hamster V79-379A cells with a half-life of 28 hr. By contrast …

DNA has been implicated as the critical target for cis-diamminedichloroplatinum (II)(cis-
DDP)-induced cytotoxicity. In vitro, DNA-platinum adducts inhibit DNA synthesis. An …

A series of cisplatin-resistant cell lines were used to examine the formation and removal of
platinum-DNA adducts from the overall genome and the formation and removal of cisplatin …

The anticancer drug cis-diamminedichloroplatinum (II)(cisplatin) has been shown previously
to form adducts preferentially within internucleosomal or linker DNA rather than to DNA …

The toxicity and mutagenicity of three DNA adducts formed by the anticancer drug cis-
diamminedichloroplatinum (II)(cis-DDP or cisplatin) were investigated in Escherichia coli …

Cisplatin is a chemotherapeutic drug widely used in the treatment of several tumours, but
this chemotherapy presents problems in terms of side-effects and patient resistance. The …