Polarization second harmonic microscopy was used for collagen imaging in human non-
small cell lung carcinoma and normal lung tissues ex vivo and revealed significant …

Multiphoton microscopy (MPM), based on two-photon excited fluorescence and second
harmonic generation, enables direct noninvasive visualization of tissue architecture and cell …

Nonlinear microscopy, namely multiphoton imaging and second harmonic generation
(SHG), is an established noninvasive technique useful for the imaging of extracellular matrix …

A polarimetric second harmonic generation (SHG) microscope was used to analyze the
dependence between polarization and SHG signal from collagen-based samples. A …

Importance of the field: Advances in nonlinear optical microscopy have led to new imaging
modalities that can be used for diagnosing pathological tissues. Intrinsic optical sectioning …

In vivo higher‐harmonic generation microscopy (HGM) performed on healthy human oral
mucosa not only provides images with a< 500 nm lateral resolution at a 280 μm penetration …

Application of multiphoton microscopy (MPM) to clinical cancer research has greatly
developed over the last few years. In this paper, we mainly focus on two-photon excitation …

Modern optics and spectroscopy offer promising noninvasive solutions that have the
potential to improve tissuebased diagnosis, as demonstrated by the extensive use of …

We utilize multiphoton microscopy for the label-free diagnosis of noncancerous, lung
adenocarcinoma (LAC), and lung squamous cell carcinoma (SCC) tissues from humans …

Several specific alterations of the extracellular matrix can be considered a distinctive
hallmark of cancer. In particular, a different morphology of the collagen scaffold is frequently …